Terminology
- Parotid Glands
- The largest of the salivary glands.
Diagnostic Biomarkers
- SS-A (Ro) Antibodies
- A type of anti-nuclear autoantibodies that are associated with many autoimmune diseases.
- SS-B (La) Antibodies
- While anti-SS-A/Ro antibodies are present in many autoimmune diseases, anti-SS-B/La antibodies are more specific to Sjögren's.
- The absence of SS-A/Ro and SS-B/La autoantibodies does not exclude Sjögren's as a cause.
- SSA and SSB antibodies
- Same as above.
- Salivary Gland Protein 1 (SP-1)
- Looks for IgG antibodies in salivary proteins.
- Carbonic Anhydrase 6 (CA6)
- Measures antibodies to an enzyme in the saliva.
- Parotid Secretory Protein (PSP)
- Looks for IgG antibodies in salivary proteins.
- Antinuclear Antibodies (ANA) using Immunofluorescence
- ANA testing is commonly used in the evaluation of systemic autoimmune rheumatic diseases.
- A positive ANA result can also be seen in various other diseases and even in healthy individuals.
- Rheumatoid Factor (RF)
- High blood serum levels may be indicative of an autoimmune disease.
- Rheumatoid factor is an autoantibody produced by the immune system that attacks your own cells.
- cathepsin S, B-cell-activating factor, and myxovirus resistance protein A
- novel
Diagnostic Testing
Quest
- Sjogren's Panel with Rheumatoid Factor and ANA, IFA with Reflex
- ?
- Early Sjogren's Syndrome Profile
- ?
Labcorp
- Sjogren's Profile Plus (RDL)
Test Number: 520196
- Includes: Anti-Ro (SS-A); Anti-La (SS-B); Anti-Fodrin Abs, IgG and IgA
- Sjögren's Antibodies (Anti-SS-A/Anti-SS-B)
- ?