Terminology

Parotid Glands
The largest of the salivary glands.

Diagnostic Biomarkers

SS-A (Ro) Antibodies
A type of anti-nuclear autoantibodies that are associated with many autoimmune diseases.
SS-B (La) Antibodies
While anti-SS-A/Ro antibodies are present in many autoimmune diseases, anti-SS-B/La antibodies are more specific to Sjögren's.
The absence of SS-A/Ro and SS-B/La autoantibodies does not exclude Sjögren's as a cause.
SSA and SSB antibodies
Same as above.
Salivary Gland Protein 1 (SP-1)
Looks for IgG antibodies in salivary proteins.
Carbonic Anhydrase 6 (CA6)
Measures antibodies to an enzyme in the saliva.
Parotid Secretory Protein (PSP)
Looks for IgG antibodies in salivary proteins.
Antinuclear Antibodies (ANA) using Immunofluorescence
ANA testing is commonly used in the evaluation of systemic autoimmune rheumatic diseases.
A positive ANA result can also be seen in various other diseases and even in healthy individuals.
Rheumatoid Factor (RF)
High blood serum levels may be indicative of an autoimmune disease.
Rheumatoid factor is an autoantibody produced by the immune system that attacks your own cells.
cathepsin S, B-cell-activating factor, and myxovirus resistance protein A
novel

Diagnostic Testing

Quest

Sjogren's Panel with Rheumatoid Factor and ANA, IFA with Reflex
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Early Sjogren's Syndrome Profile
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Labcorp

Sjogren's Profile Plus (RDL) Test Number: 520196
Includes: Anti-Ro (SS-A); Anti-La (SS-B); Anti-Fodrin Abs, IgG and IgA
Sjögren's Antibodies (Anti-SS-A/Anti-SS-B)
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