Review Articles

Small ORFs, Big Insights: Drosophila as a Model to Unraveling Microprotein Functions Chanut-Delalande et al. 2024 Review Article

"We summarize the technical challenges associated with identifying putative coding smORFs in the genome and the relevant translated microproteins. Finally, recent findings on one of the best studied smORF peptides, Pri, and other microproteins studied so far in Drosophila are described."

Micropeptides Identified from Human Genomes Yuanyuan et al. 2022 Review Article

"Here, we provide a review of human micropeptides encoded by various transcripts such as mitochondrial rRNAs, long noncoding RNAs, circularRNAs, upstream of mRNAs, and so on."

Small Open Reading Frame-Encoded Micro-Peptides: An Emerging Protein World Dong et al. 2023 Review Article

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The alternative proteome in neurobiology Mohaupt et al. 2022 Review Article

"Recent ribosome sequencing (Ribo-seq) and proteomics studies show that, in addition to currently annotated reference proteins (RefProt), other proteins termed alternative proteins (AltProts), and microproteins are encoded in regions of mRNAs thought to be untranslated or in transcripts annotated as non-coding."

"This review explores the hitherto overlooked alternative proteome in neurobiology and considers the role of AltProts in pathological and healthy neuromolecular processes."

Microproteins-Discovery, structure, and function Xiao et al. 2024 Review Article

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Large Roles of Small Proteins Burton et al. 2024 Author Manuscript

"Here, we provide an overview of these diverse functions in bacteria, highlighting generalities among bacterial small proteins and similarly sized proteins in eukaryotic organisms and discussing questions for future research."

Research Articles

Extensive identification and analysis of conserved small ORFs in animals Mackowiak et al. 2015 Research Article

"Taken together, we identify hundreds of previously unknown conserved sORFs in major model organisms."

"We thus provide an integrated resource of putatively functional micropeptides for functional validation in vivo."

Uncategorized

Finding functional microproteins Azam et al. 2025 Author Manuscript

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Mining for Micropeptides Makarewich et al. 2017 Author Manuscript

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Microproteins in Metabolism Wadding-Lee et al. 2025 Review Article

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The Small Open Reading Frame-Encoded Peptides: Advances in Methodologies and Functional Studies ? ? Article

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Casting CRISPR-Cas13d to fish for microprotein functions in animal development Treichel et al. 2022 Review Article

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Eukaryotic Microproteins Jaunbocus et al. 2025 Review Article

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Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications ? ? Article

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Noncanonical microprotein regulation of immunity ? ? Article

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https://pubmed.ncbi.nlm.nih.gov/40020329/