Research Articles

Prenatal hypoxia produces memory deficits associated with impairment of long-term synaptic plasticity in young rats ? ? Research Article

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Oxygen metabolism and oxygenation of the newborn Andresen et al. 2020 Review Article

"The premature infant is to some extent protected from hypoxia, however defense against hyperoxia is poorly developed."

"In the lungs of newborn mice reoxygenated with hyperoxia (60 or 100% oxygen) differentially expression of several hundreds of genes was induced compared to reoxygenation with air. This effect was enhanced remarkably when hyperoxia followed hypoxia with almost a doubling of induced genes. Hyperoxia resulted in up-regulation of genes related to HIF-1 responsive genes, pathways related to cell cycling, nucleotide excision, nucleotide excision repair, mammalian target of rapamycin (mTOR) signaling pathway including genes related to growth (VegfC, Pgf) and signal transduction. DNA polymerase was downregulated by hyperoxia, hence reducing DNA replication."

"In the mouse brain, hyperoxia down regulated genes related to DNA replication and to oxidative phosphorylation and increased cell death in the brainstem. In general, following hypoxia, hyperoxic reoxygenation induced a stronger brain inflammatory gene response than reoxygenation with air."

The Oxygen Load Supplied during Delivery Room Stabilization of Preterm Infants Modifies the DNA Methylation Profile ? ? Research Article

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Hyperoxia induces epigenetic changes in newborn mice lungs ? ? Research Article

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Genome-Wide Analysis of DNA Methylation in Hyperoxia-Exposed Newborn Rat Lung ? ? Research Article

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Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation Rognlien et al. 2015 Research Article

"Postnatal day 7 mice were subjected to 2 h of hypoxia (8% O2) and 30 min reoxygenation with 60% or 21% O2. After 0 to 72 h observation, mRNA and protein were examined in the hippocampus and striatum."

transcriptome profiling of the newborn mouse brain after hypoxia–reoxygenation: hyperoxic reoxygenation induces inflammatory and energy failure responsive genes ? ? Research Article

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Impact of Room Air Resuscitation on Early Growth Response Gene-1 in a Neonatal Piglet Model of Cerebral Hypoxic Ischemia ? ? Research Article

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Temporal Patterns of Gene Expression Profiles in the Neonatal Mouse Lung after Hypoxia-Reoxygenation ? ? Research Article

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transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mtor signaling pathway, dna repair, and Jnk-pathway regulation ? ? Research Article

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The emerging intertwined activities of metabolism and epigenetics unveils culprits and prospects in cancer ? ? Research Article

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Alpha-Ketoglutarate: A Metabolic Regulator of Cellular Homeostasis and Pathophysiology ? ? Research Article

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Differential Effects of Normoxic and Hyperoxic Reperfusion on Global Myocardial Ischemia-Reperfusion Injury ? ? Research Article

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