Research Articles

Prenatal hypoxia produces memory deficits associated with impairment of long-term synaptic plasticity in young rats Zhuravin et al. 2019 Research Article

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The Oxygen Load Supplied during Delivery Room Stabilization of Preterm Infants Modifies the DNA Methylation Profile Lorente-Pozo et al. 2018 Research Article 10.1016/j.jpeds.2018.07.009

"The oxygen load provided upon resuscitation modified the DNA methylome. Differential methylation may lead to altered expression of genes related to cell cycle progression, oxidative stress, and DNA repair. The reversibility of these early epigenetic changes is unknown but merits further study."

Hyperoxia induces epigenetic changes in newborn mice lungs Bik-Multanowski et al. 2018 Research Article 10.1016/j.freeradbiomed.2018.04.566

"Supplemental oxygen exposure is a risk factor for the development of bronchopulmonary dysplasia (BPD). Reactive oxygen species may damage lung tissue, but hyperoxia also has the potential to alter genome activity via changes in DNA methylation."

"Here we aimed to identify hyperoxia-related alterations in DNA methylation, which could affect the activity of crucial genetic pathways involved in the development of hyperoxic lung injury."

"Newborn mice (n=24) were randomized to hyperoxia (85% O2) or normoxia groups for 14 days, followed by normoxia for the subsequent 14 days."

"The meanDNAmethylation level was higher in the hyperoxia group than the normoxia group. The analysis of specific DNA fragments revealed hypermethylation of> 1000 gene promoters in the hyperoxia group, confirming the presence of the DNA-hypermethylation effect of hyperoxia."

Genome-Wide Analysis of DNA Methylation in Hyperoxia-Exposed Newborn Rat Lung Chen et al. 2017 Research Article 10.1007/s00408-017-0036-z

"Our in vivo model revealed that neonatal hyperoxia exposure arrested alveolarization on Postnatal Day 14."

"We found that the ErbB, actin cytoskeleton, and focal adhesion signaling pathways are epigenetically modulated by exposure to hyperoxia. We demonstrated that hyperoxia exposure contribute in delaying lung development through an epigenetic mechanism by disrupting the expression of genes in lungs that might be involved in alveolarization.

"These data indicate that aberrant DNA methylation and deregulation of the actin cytoskeleton and focal adhesion pathways of lung tissues may be involved in the pathophysiology of hyperoxia-induced arrested alveolarization."

Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation Rognlien et al. 2015 Research Article 10.1038/pr.2014.193

"Postnatal day 7 mice were subjected to 2 h of hypoxia (8% O2) and 30 min reoxygenation with 60% or 21% O2. After 0 to 72 h observation, mRNA and protein were examined in the hippocampus and striatum."

Transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mtor signaling pathway, dna repair, and Jnk-pathway regulation Wollen et al. 2013 Research Article

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Transcriptome profiling of the newborn mouse brain after hypoxia–reoxygenation: hyperoxic reoxygenation induces inflammatory and energy failure responsive genes Wollen et al. 2014 Research Article

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Review Articles

Oxygen metabolism and oxygenation of the newborn Andresen et al. 2020 Review Article 10.1016/j.siny.2020.101078

"The premature infant is to some extent protected from hypoxia, however defense against hyperoxia is poorly developed."

"In the lungs of newborn mice reoxygenated with hyperoxia (60 or 100% oxygen) differentially expression of several hundreds of genes was induced compared to reoxygenation with air. This effect was enhanced remarkably when hyperoxia followed hypoxia with almost a doubling of induced genes. Hyperoxia resulted in up-regulation of genes related to HIF-1 responsive genes, pathways related to cell cycling, nucleotide excision, nucleotide excision repair, mammalian target of rapamycin (mTOR) signaling pathway including genes related to growth (VegfC, Pgf) and signal transduction. DNA polymerase was downregulated by hyperoxia, hence reducing DNA replication."

"In the mouse brain, hyperoxia down regulated genes related to DNA replication and to oxidative phosphorylation and increased cell death in the brainstem. In general, following hypoxia, hyperoxic reoxygenation induced a stronger brain inflammatory gene response than reoxygenation with air."

Uncategorized

Impact of Room Air Resuscitation on Early Growth Response Gene-1 in a Neonatal Piglet Model of Cerebral Hypoxic Ischemia Tyree et al. 2006 Research Article

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Temporal Patterns of Gene Expression Profiles in the Neonatal Mouse Lung after Hypoxia-Reoxygenation Rognlien et al. 2016 Research Article

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Differential Effects of Normoxic and Hyperoxic Reperfusion on Global Myocardial Ischemia-Reperfusion Injury Peng et al. 2018 Research Article

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