Terminology

Microglia

Resident innate immune cells in the central nervous system (CNS) that serve as the first line innate immunity in response to pathogen invasion, ischemia and other pathological stimuli.

Once activated, they rapidly release a variety of inflammatory cytokines and phagocytose pathogens or cell debris (termed neuroinflammation), which is beneficial for maintaining brain homeostasis if appropriately activated.

Mitophagy

Clearing damaged or redundant mitochondria, ensuring mitochondrial homeostasis and senescence.

Uncategorized

XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks ??? et al. ??? Highlight

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Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells ??? et al. ??? Highlight

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GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1 ??? et al. ??? Highlight

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OsMre11 Is Required for Mitosis during Rice Growth and Development ??? et al. ??? Highlight

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The dynamic nature of the Mre11-Rad50 DNA break repair complex ??? et al. ??? Highlight

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Distinct mechanisms for genomic attachment of the 5' and 3' ends of Agrobacterium T-DNA in plants ??? et al. ??? Highlight

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Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks ??? et al. ??? Highlight

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Structure-function relationships of the Mre11 protein in the control of DNA end bridging and processing ??? et al. ??? Highlight

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20 Years of Mre11 Biology: No End in Sight ??? et al. ??? Highlight

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Methylation of MRE11 regulates its nuclear compartmentalization ??? et al. ??? Highlight

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Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles ??? et al. ??? Highlight

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Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges ??? et al. ??? Highlight

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Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications ??? et al. ??? Highlight

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Extracellular vesicles as a next-generation drug delivery platform ??? et al. ??? Highlight

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Desiccation tolerance in plants: Structural characterization of the cell wall hemicellulosic polysaccharides in three Selaginella species ??? et al. ??? Highlight

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Desiccation Tolerance as the Basis of Long-Term Seed Viability ??? et al. ??? Highlight

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Unexplored dimensions of variability in vegetative desiccation tolerance ??? et al. ??? Highlight

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Caenorhabditis Elegans as a Model for Environmental Epigenetics ??? et al. ??? Highlight

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Lactate promotes longevity through redox-driven lipid remodeling in Caenorhabditis elegans ??? et al. ??? Highlight

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Metabolic enzymes aldo-2 and pdhb-1 as potential epigenetic regulators during C. elegans embryogenesis ??? et al. ??? Highlight

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Glycolysis: A multifaceted metabolic pathway and signaling hub ??? et al. ??? Highlight

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Roles of microglial mitophagy in neurological disorders Liu et al. 2022 Review Article

"Microglia are highly dynamic cells, dependent on energy supply from mitochondria. Moreover, dysfunctional mitochondria can serve as a signaling platform to facilitate innate immune responses in microglia."

"This article reviews and highlights the role and regulation of mitophagy in microglia in neurological conditions, and the research progress in manipulating microglial mitophagy and future directions in this field are also discussed."

Review Articles

Vitamin A: too good to be bad? Chen et al. 2023 Review Article

"Strikingly, different animal disease models also respond to vitamin A statuses differently or even opposing."

"In this review, we discuss some of these controversial issues in understanding vitamin A biology."