Terminology

Embryonic Diapause

Temporary halt to an embryo's development to wait for more favorable environmental conditions.

Research Articles

Transgenerational adaptation to hypoxia Kim et al. 2025 Research Article 10.1126/sciadv.adv9451

"We found that parental hypoxia exposure increased P0 longevity, caused intergenerational lipid reduction, and elicited transgenerational fertility reduction that was dependent on generationally transmitted small RNAs."

"Here, we find that Caenorhabditis elegans adapt to repeated generational stresses. We show that, upon two repeated generational hypoxia exposures, the life-span extension is eliminated, and after four repeated generational hypoxia exposures, the reduced fertility is eliminated."

"Transgenerational hypoxia adaptation is dependent on the H3K27 trimethyltransferase PRC2 complex, and we identified transgenerationally adapted genes."

"Our findings reveal that transgenerational adaptation occurs and suggest that H3K27me3 is a critical modification for adapting to repeated generational stresses."

Genetic analysis of hypoxia signaling and response in C elegans Shen et al. 2003 Research Article

"Here, we briefly review the characterization of C. elegans hif-1 and interacting genes, and discuss genetic strategies for studying hypoxia signaling and response."

Hypoxia signaling and resistance in C. elegans Powell-Coffman 2010 Author Manuscript

"This review provides an overview of C. elegans responses to hypoxia, ranging from adaptation and arrest to death, and highlights some of the recent studies that have provided important insights into hypoxia signaling and resistance."

Hypoxia induces transgenerational epigenetic inheritance of small RNAs Wang et al. 2023 Author Manuscript

"We show that hypoxia educes an intergenerational reduction in lipids and a transgenerational reduction in fertility in the nematode Caenorhabditis elegans."

"Feeding naive C. elegans small RNAs extracted from hypoxia-treated worms is sufficient to induce a fertility defect.

"Furthermore, the endogenous small interfering RNA F44E5.4/5 is upregulated intergenerationally in response to hypoxia, and soaking naive normoxia-reared C. elegans with F44E5.4/5 double-stranded RNA (dsRNA) is sufficient to induce an intergenerational fertility defect."

C. Elegans are Protected from Lethal Hypoxia by an Embryonic Diapause Miller et al. 2009 Author Manuscript

"Diapausing embryos in utero require san-1 to survive, indicating that hypoxia-induced embryonic diapause may be mechanistically related to suspended animation."

"Furthermore, we show that neuronal HIF-1 activity in the adult dictates the O2 tension at which embryonic diapause is engaged."

"We suggest that the maternal perception of hypoxia stimulates a response to protect embryos in utero by inducing diapause, a natural form of suspended animation."

Methodology

Creating Defined Gaseous Environments to Study the Effects of Hypoxia on C. elegans Fawcett et al. 2012 Video Article

"Here, we present a method for the construction and implementation of environmental chambers that produce reliable and reproducible hypoxic conditions with defined concentrations of O2."

Uncategorized

Characterization of sub-nuclear changes in Caenorhabditis elegans embryos exposed to brief, intermediate and long-term anoxia to analyze anoxia-induced cell cycle arrest ? ? Research Article

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Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans ? ? Research Article

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Adaptation to Temporally Fluctuating Environments by the Evolution of Maternal Effects ? ? Research Article

"Theory predicts that the evolution of deterministic maternal effects (i.e., anticipatory maternal effects or transgenerational phenotypic plasticity) underlies adaptation to environments that fluctuate in a predictably alternating fashion over maternal-offspring generations."

"In contrast, randomizing maternal effects (i.e., diversifying and conservative bet-hedging), are expected to evolve in response to unpredictably fluctuating environments."

"At odds with existing theory, however, populations facing irregularly fluctuating normoxia–anoxia hatching environments failed to evolve randomizing maternal effects. Instead, adaptation in these populations may have occurred through the evolution of fitness effects that percolate over multiple generations, as they maintained considerably high expected growth rates during experimental evolution despite evolving reduced fecundity and reduced embryo survival under one or two generations of anoxia."

microRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans ? ? Research Article

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Hypoxia and the endometrium: An indispensable role for HIF-1α as therapeutic strategies ? ? Research Article

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Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse ? ? Research Article

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In Vivo Expression of mRNAs Encoding Hypoxia-Inducible Factor 1 ? ? Research Article

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Adaptive sugar provisioning controls survival of C. elegans embryos in adverse environments ? ? Author Manuscript

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Suspended animation, diapause and quiescence Arresting the cell cycle in C. elegans ? ? Review Article

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PQM-1 controls hypoxic survival via regulation of lipid metabolism ? ? Research Article

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Carbon monoxide-induced suspended animation protects against hypoxic damage in Caenorhabditis elegans ? ? Research Article

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Fresh air is good for nerves: hypoxia disturbs axon guidance ? ? Research Article

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Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans ? ? Research Article

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Asphyxia, Therapeutic Hypothermia, and Pulmonary Hypertension ? ? Review Article

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Contribution of microglia to the epileptiform activity that results from neonatal hypoxia ? ? Research Article

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The Epigenetics of Germ-line Immortality: Lessons from an Elegant Model System ? ? Author Manuscript

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Epimutations: raw material for evolution? Ganem et al. 2026 Review Article

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Caenorhabditis elegans: An Old Genetic Model Can Learn New Epigenetic Tricks ? ? Symposium

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Lineage Tracing and Single-Cell RNA-seq in C. elegans to Analyze Transgenerational Epigenetic Phenotypes Inherited from Germ Cells ? ? NO PDF 10.1007/978-1-0716-3259-8_3

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Worm Perturb-Seq: massively parallel whole animal RNAi and RNA-seq ? ? Methodology

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Temporal transcriptomic profiling reveals distinct age-associated gene expression signatures in gonads under reduced insulin/IGF-1 signaling in Caenorhabditis elegans ? ? Research Article

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The Caenorhabditis RNA-seq Browser: a web-based application for on demand analysis of publicly available Caenorhabditis spp. bulk RNA sequencing data. ? ? Data Article

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A meta-analysis of RNA-Seq studies to identify novel genes that regulate aging ? ? Author Manuscript

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