Terminology

Acclimation Reversible: Occurs within the lifetime of an organism.; Does not produce a novel phenotypic trait; hence, it does not proceed through natural selection.; Allows organisms to adjust their morphological, behavioural, physical, and/or biochemical traits in response to changes in their environment.
Adaptation Irreversible: Occurs over several generations.; Produces a novel phenotypic trait that has a functional role in the environment and therefore, it proceeds through natural selection.; Allows organisms to fit their environment by enhancing their evolutionary fitness.
Gene-by-Environment Interactions: When two different genotypes respond to environmental variation in different ways.

Review Articles

Epigenetics and cytoprotection with heat acclimation Horowitz 2015 Review Article

"The heat-acclimated phenotype confers cytoprotection against novel stressors via cross-tolerance mechanisms, by attenuation of the initial damage and/or by accelerating spontaneous recovery through the release of help signals."

"This indispensable acclimatory feature has a memory and can be rapidly reestablished after the loss of acclimation and the return to the physiological preacclimated phenotype."

"We suggest that these orchestrated responses maintain euchromatin and proteostasis during deacclimation and predispose to rapid reacclimation and cytoprotection. These mechanisms represent within-life epigenetic adaptations and cytoprotective memory."

Gene-by-environment interactions in Alzheimer’s disease and Parkinson’s disease Dunn et al. 2019 Review Article

"Here, we highlight recent approaches and ongoing developments in human and rodent studies to identify genetic modulators of environmental factors using AD and PD as exemplars."

Research Articles

Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain Zhou et al. 2023 Research Article: "Here, we identify a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow (BM) of mice and humans that experienced dieting-induced weight loss."; "Adoptive transfer of CD7+ monocytes suppresses weight regain, whereas inducible depletion of CD7+ monocytes accelerates it."; "These cells, accumulating metabolic memories via epigenetic adaptations, preferentially migrate to the subcutaneous white adipose tissue (WAT), where they secrete fibrinogen-like protein 2 (FGL2) to activate the protein kinase A (PKA) signaling pathway and facilitate beige fat thermogenesis."; "Nevertheless, CD7+ monocytes gradually enter a quiescent state after weight loss, accompanied by increased susceptibility to weight regain."; "Notably, administration of FMS-like tyrosine kinase 3 ligand (FLT3L) remarkably rejuvenates CD7+ monocytes, thus ameliorating rapid weight re gain."
Epigenetic regulation of sulfur homeostasis in plants Huang et al. 2019 Research Article: "We summarize and discuss recent findings on the epigenetic regulation of sulphur homeostasis and response to sulphur deficiency in plants, including DNA methylation, histone modifications and noncoding RNA mediated gene silencing."

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A Comprehensive Understanding of Dietary Effects on C. elegans Physiology Zhou et al. 2019 Review Article: "To reveal novel signaling pathways responsive to different diets, C. elegans and its bacterial diet were used as an interspecies model system to mimic the interaction between host and gut microbiota."
Experimental Approaches for Testing if Tolerance Curves Are Useful for Predicting Fitness in Fluctuating Environments et al. Article: ?
A Numerical Model Supports the Evolutionary Advantage of Recombination Plasticity in Shifting Environments et al. NO PDF: ?
Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity et al. Article: ?
Epigenomic plasticity of Arabidopsis msh1 mutants under prolonged cold stress et al. Article: ?
Timescales of human adaptation: the role of epigenetic processes Kuzawa et al. 2011 Article: ?
Training Load Oscillation and Epigenetic Plasticity: Molecular Pathways Connecting Energy Metabolism and Athletic Personality Mănescu 2026 Review Article: "This narrative review examines how training load oscillation (TLO)—the deliberate variation in exercise intensity, volume, and substrate availability—may function as a systemic epigenetic stimulus capable of shaping both physiological and psychological adaptation."
Role of oxygen sensing and hypoxia-inducible factors in orchestrating innate immune responses Low et al. 2025 Review Article: "In this Review, we summarize how acute and chronic hypoxia influence innate immune cell function and metabolism, thereby tailoring immune cell behavior within the tissue microenvironment."; "We further highlight the dual roles of hypoxia in regulating innate immune cell function in different (patho)physiological contexts and evaluate therapeutic strategies that target oxygen-sensing pathways to restore immune competence and tissue homeostasis."
Integrated temporal transcriptional and epigenetic single-cell analysis reveals the intrarenal immune characteristics in an early-stage model of IgA nephropathy during its acute injury et al. Article: ?
Advances and applications of environmental stress adaptation research Hawkins et al. 2019 Review Article: "Concluding, we examine some of the human applications that can be gained from understanding the principles of biochemical adaptation including organ preservation and treatments for conditions such as ischemic stroke and muscle disuse atrophy."
Fluctuating asymmetry: an epigenetic measure of stress Parsons 1989 Article: ?
BCL6 regulates brown adipocyte dormancy to maintain thermogenic reserve and fitness et al. Article: ?
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas et al. Article: ?
Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clam Laternula elliptica et al. Article: ?
Hyperosmotic priming of Arabidopsis seedlings establishes a long-term somatic memory accompanied by specific changes of the epigenome et al. Article: ?
Benchmarking sample pooling for epigenomics of natural populations et al. Article: ?
Plant Epigenetic Stress Memory Induced by Drought: A Physiological and Molecular Perspective et al. NO PDF: ?
Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics et al. Article: ?
Acclimatization and Adaptive Capacity of Marine Species in a Changing Ocean et al. Article: ?
Cold stress induces rapid gene-specific changes in the levels of H3K4me3 and H3K27me3 in Arabidopsis thaliana et al. Article: ?
Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans et al. Article: ?
Cold Tolerance in the Nematode Caenorhabditis elegans Kuhara et al. 2024 Review Article: "We introduce the mechanisms underlying cold tolerance and temperature acclimation in a model organism—the nematode Caenorhabditis elegans, at molecular and physiological levels."
Role of gene body methylation in acclimatization and adaptation in a basal metazoan Dixon et al. 2018 Article: ?
Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice et al. Article: ?
Distinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A et al. Article: ?

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