Research Articles

Natural variations of cold tolerance and temperature acclimation in Caenorhabditis elegans Okahata et al. 2016 Research Article

"In this study, we demonstrated natural variations in the phenotypes of temperature tolerance and temperature acclimation of the nematode Caenorhabditis elegans, and we decoded whole genome sequence of six natural variations, which enabled us to map responsible gene polymorphisms onto specific chromosomal regions."

"The C. elegans laboratory strain, N2, survives at 2 °C after cultivation at 15 °C but is unable to survive at 2 °C after cultivation at 20 or 25 °C."

• "This cultivation-temperature-dependent cold tolerance occurs within a few hours after the temperature shift and is termed cold acclimation."

HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans Treinin et al. 2003 Research Article

"[Heat acclimation] attained by maintaining adult C. elegans at 25°C for 18 h enhanced heat endurance of wild-type worms subjected to heat stress (35°C) and conferred protection against hypoxia and cadmium."

"We conclude that HIF-1 upregulation is both an evolutionarily conserved and a necessary component of heat acclimation."

"The known targets of HIF-1 imply that metabolic adaptations are essential for [heat acclimation]-dependent tolerance to heat and heavy metals, in addition to their known role in hypoxic adaptation."