Research Articles

A histone methylation network regulates transgenerational epigenetic memory in C. elegans ? ? Author Manuscript

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Hypoxia induces transgenerational epigenetic inheritance of small RNAs Wang et al. 2023 Author Manuscript

"We show that hypoxia educes an intergenerational reduction in lipids and a transgenerational reduction in fertility in the nematode Caenorhabditis elegans."

"Feeding naive C. elegans small RNAs extracted from hypoxia-treated worms is sufficient to induce a fertility defect.

"Furthermore, the endogenous small interfering RNA F44E5.4/5 is upregulated intergenerationally in response to hypoxia, and soaking naive normoxia-reared C. elegans with F44E5.4/5 double-stranded RNA (dsRNA) is sufficient to induce an intergenerational fertility defect."

Intergenerational Transmission of Gene Regulatory Information in Caenorhabditis elegans Minkina et al. 2019 Author Manuscript

"The nematode Caenorhabditis elegans has been particularly instrumental in the effort to understand TEI, as multiple environmental and genetic triggers can initiate an epigenetic signal that can alter the expression of both transgenes and endogenous loci."

Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans Chey et al. 2023 Author Manuscript 10.1016/j.tig.2021.08.011

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Uncategorized

A unified framework governing the establishment and maintenance of transgenerational epigenetic inheritance ? ? Investigation

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Bridging the transgenerational gap with epigenetic memory ? ? Author Manuscript

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A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans Houri-Ze’evi et al. 2016 Author Manuscript

"The duration of epigenetic responses underpinning transgenerational inheritance is determined by an active mechanism relying on the production of small RNAs and modulation of RNAi factors, dictating whether ancestral RNAi responses would be memorized or forgotten."

A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance Houri-Zeevi et al. 2016 Review Article

"Amplification of small RNAs via RNA dependent RNA polymerases, and competition between different small RNA species, emerge as key processes that determine the potency and duration of heritable RNAi responses."

Epigenetic “Transgenerational” Inheritance Luft 2022 Editorial

"Proposed molecular mechanism of transgenerational inheritance of hypertension."

"Lipopolysaccharides (LPSs) applied prenatally induce reactive oxygen species (ROS) that indirectly upregulate the lysine (K)-specific demethylase 3B (KDMB3)."

Molecular mechanisms of transgenerational epigenetic inheritance Fitz-James et al. 2026 Author Manuscript

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Transgenerational Epigenetic Inheritance ? ? Review Article

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Small RNAs Worm Up Transgenerational Epigenetics Research ? ? Author Manuscript

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Intraspecific variation in the duration of epigenetic inheritance Frejacques et al. 2025 Author Manuscript

"We find that the presence and the duration of silencing in number of generations differ across C. elegans wild strains."

"We further show that the duration of silencing memory in wild strains is quite robust to environmental variation such as diet and passage through larval diapauses, but not to temperature variation."

The third barrier to transgenerational inheritance in animals: somatic epigenetic resetting Ewe et al. 2023 Commentary

"We discuss three major barriers to TEI in animals, two of which, the “Weismann barrier” and germline epigenetic reprogramming, have been known for decades."

• "These are thought to effectively prevent TEI in mammals but not to the same extent in C. elegans."

"We argue that a third barrier—that we termed “somatic epigenetic resetting”—may further inhibit TEI and, unlike the other two, restricts TEI in C. elegans as well."

Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans ? ? NO PDF 10.1016/j.cub.2026.02.040

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