in C. elegans

Last Updated
2026-06-01
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A histone methylation network regulates transgenerational epigenetic memory in C. elegans ? ? Author Manuscript
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Hypoxia induces transgenerational epigenetic inheritance of small RNAs Wang et al. 2023 Author Manuscript
"We show that hypoxia educes an intergenerational reduction in lipids and a transgenerational reduction in fertility in the nematode Caenorhabditis elegans."
"Feeding naive C. elegans small RNAs extracted from hypoxia-treated worms is sufficient to induce a fertility defect.
"Furthermore, the endogenous small interfering RNA F44E5.4/5 is upregulated intergenerationally in response to hypoxia, and soaking naive normoxia-reared C. elegans with F44E5.4/5 double-stranded RNA (dsRNA) is sufficient to induce an intergenerational fertility defect."