"Future efforts should prioritize optimized dosing and combinatorial regimens, alongside biomarker-guided patient selection and more targeted epigenetic approaches to improve efficacy, especially in solid tumors."
Research Articles
Vitamin C Promotes Epidermal Proliferation by Promoting DNA Demethylation of Proliferation-Related Genes in Human Epidermal Equivalents
Sato et al. 2025
Research Article
"[Vitamin C] is a cofactor for the DNA demethylation (ten-eleven translocation) enzyme."
"DNA microarray and whole-genome bisulfite sequencing analyses revealed that 12 genes related to cell proliferation were significantly upregulated by [vitamin C]. Furthermore, hypomethylated DNA regions associated with these genes were revealed in the presence of [vitamin C]."
"Collectively, our findings provide insight into how [vitamin C] increases epidermal thickness by promoting keratinocyte proliferation through the DNA demethylation of proliferation-related genes."
Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes
Shen et al. 2014
Author Manuscript
"For both genomes, our data indicate that replication-dependent dilution is the major contributor to demethylation, but Tet3 plays an important role, particularly at certain loci."