Terminology

Review Articles

DNA methyltransferase inhibitors in oncology: clinical progress, limitations and future directions Michael et al. 2026 Review Article: "By reversing aberrant DNA hypermethylation, DNMTis restore silenced tumor suppressor pathways, induce cellular differentiation, trigger DNA-damage-driven apoptosis, and enhance tumor immunogenicity."; "Future efforts should prioritize optimized dosing and combinatorial regimens, alongside biomarker-guided patient selection and more targeted epigenetic approaches to improve efficacy, especially in solid tumors."

Vitamin C Promotes Epidermal Proliferation by Promoting DNA Demethylation of Proliferation-Related Genes in Human Epidermal Equivalents Sato et al. 2025 Research Article: "[Vitamin C] is a cofactor for the DNA demethylation (ten-eleven translocation) enzyme."; "DNA microarray and whole-genome bisulfite sequencing analyses revealed that 12 genes related to cell proliferation were significantly upregulated by [vitamin C]. Furthermore, hypomethylated DNA regions associated with these genes were revealed in the presence of [vitamin C]."; "Collectively, our findings provide insight into how [vitamin C] increases epidermal thickness by promoting keratinocyte proliferation through the DNA demethylation of proliferation-related genes."
Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes Shen et al. 2014 Author Manuscript: "For both genomes, our data indicate that replication-dependent dilution is the major contributor to demethylation, but Tet3 plays an important role, particularly at certain loci."