Review Articles

Caenorhabditis elegans: A Convenient In Vivo Model for Assessing the Impact of Food Bioactive Compounds on Obesity, Aging, and Alzheimer's Disease Shen et al. 2018 Review Article

"Compared to traditional animal models, this eukaryotic, multi-organ organism possesses many advantages, including small size (∼1 mm in length for adults), short life span (∼21 days for wild type), large progeny production (∼300 by self-fertilization), and a completely sequenced and well-annotated genome."

"Furthermore, it encodes more than 65% of the characterized human disease-related genes, and research using C. elegans does not require approval by the Institutional Animal Care and Use Committees."

"Specifically, C. elegans has been widely applied as an alternative model for genetic mechanistic studies because of the availability of broad genetic tools, including targeted deletions, mutagenesis screens, and a genome-scale RNA interference (RNAi) screen (Shen et al. 2017a)."

Research Articles

Effect of the diet type and temperature on the C. elegans transcriptome Gómez-Orte et al. 2017 Research Article

"When C. elegans were fed E. coli and the growth temperature was increased, we observed an enhancement of defense response pathways and down-regulation of genes associated with metabolic functions."

"When C. elegans were fed B. subtilis and the growth temperature was increased, the nematodes exhibited a decrease in defense response pathways and an enhancement of expression of genes associated with metabolic functions."

Reference quantitative transcriptome dataset for adult Caenorhabditis elegans Piovesan et al. 2019 Data Article 10.1016/j.dib.2019.104152

"We provide an integrated, quantitative reference map for the transcriptome of whole, wild type Bristol N2 strain C. elegans worms."

"The map provides easy access to relationships among expression values of different genes in this standard condition, highlights genomic segments with relatively high over-/under-expression and may serve as a reference to test for gene expression variation for both individual genes and the whole transcriptome in specific biological conditions (e.g. mutated strains or differently grown worms)."

• "Reference table for a quantitative gene expression value for each of the 45,932 Caenorhabditis elegans transcripts, offering the possibility for immediate establishment of quantitative relative ratio of expression for every pair of desired genes as well as analysis of global patterns of expression with any tool of gene expression profile elaboration."

• "Benchmark to identify variation in individual gene expression value following comparison with gene profiles derived by worms in different biological conditions, e.g. different developmental stages, different feeding conditions or treatments, strains with knockdown of specific genes or with any type of genetic difference."

• "Possibility to select genes with the desired features of the expression values (high/low, with high or low standard deviation from the mean among a large number of individuals, usefulness as a reference gene in gene expression studies).

• "Possibility to select genomic segments with high/low expression values (mean of expression values of the genes contained in the segment), thus also identifying genomic open chromatin domains."

• "The quantitative reference values of the enzyme mRNAs might be used in metabolic network models for the validation of hypotheses about the relationships among mRNA levels, corresponding enzymatic proteins and the quantities of their substrates or products obtained by metabolome experiments."

Uncategorized

Modeling Alzheimer's Disease in Caenorhabditis elegans et al. Article

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A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide et al. Article

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Oxidative stress mechanisms underlying Parkinson's disease-associated neurodegeneration in C. elegans et al. Article

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Defense against oxidative stress in Caenorhabditis elegans by dark tea et al. Article

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Application of Caenorhabditis elegans for Research on Endoplasmic Reticulum Stress et al. Article

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https://pubmed.ncbi.nlm.nih.gov/34673252/ https://pubmed.ncbi.nlm.nih.gov/23428113/ https://pubmed.ncbi.nlm.nih.gov/38880519/ https://pubmed.ncbi.nlm.nih.gov/37710009/ https://pubmed.ncbi.nlm.nih.gov/37149409/ https://pubmed.ncbi.nlm.nih.gov/41724566/