Research Articles

Genome-Wide DNA Methylation Changes Associated With High-Altitude Acclimatization During an Everest Base Camp Trek Childebayeva et al. 2021 Research Article

"We determined genome-wide DNA methylation levels using the Illumina MethylationEPIC chip comparing two altitudes: baseline 1,400 m (day 0) and elevation 4,240 m (day 7)."

"These findings shed light on the genes and pathways experiencing the most epigenetic change associated with short-term exposure to hypoxia."

Genome-wide DNA methylation changes after 24 hours at high altitude Frost et al. 2026 Research Article

"Twelve healthy sea-level residents, aged 19–32 years, traveled to 3800 m, and DNA from peripheral blood mononuclear cells was collected both at sea level and after 24 h at high altitude."

"We identified 58,046 differentially methylated positions at high altitude compared to sea level, with a large majority of these sites showing increased methylation levels at high altitude, supporting the hypothesis that acute exposure to hypoxia may result in global hypermethylation."

DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude Childebayeva et al. 2019 Research Article

"We collected saliva samples from a group of healthy adults of European ancestry (n = 21) in Kathmandu (1,400 m; baseline) and three altitudes during a trek to the Everest Base Camp: Namche (3,440 m; day 3), Pheriche (4,240 m; day 7), and Gorak Shep (5,160 m; day 10)."