Tendinopathy

Tendinitis Genes

Key Takeaways

Tendinitis is due to disorganized collagen bundles in the tendon.
Chronically elevated inflammatory cytokines cause the remodeling of the tendon to be disrupted.
Understanding where your genetic susceptibility lies can help you target the right solutions to heal – and prevent – tendinitis.

Gene	RS ID	Your Genotype	Notes for Your Genotype	Effect allele	Effect allele frequency
GDF5	rs143383	AG	less of a risk of Achilles tendon problems	G	0.57
COL1A1	rs1800012	AC	typical risk for Achilles tendon tear	A	0.16
COL5A1	rs12722	TT	higher risk of Achilles tendinopathy (lower levels of COL5A1); increased risk of tennis elbow	T	0.49
MIR608	rs4919510	CC	typical	G	0.21
BMP4	rs2761884	GT	increased risk of tendinopathies	T	0.40
FCRL3	rs7528684	AG	increased risk of tendinopathies	G	0.45
TNF	rs1800629	GG	typical, better response to high protein/low carb diet	A	0.15
MMP13	rs2252070	TT	common genotype; increased risk of posterior tibial tendon problems (flat foot)	C	0.68
MMP1	rs1144393	CC	increased risk of posterior tibial tendon problems	C	0.35
MMP3	rs650108	GG	increased risk of tendinopathies (high-level athletes)	G	0.72
MMP3	rs679620	TT	increased risk of tendinopathies (high-level athletes)	T	0.48