Key Takeaways
- The COMT gene encodes a key enzyme for regulating neurotransmitter levels.
- Common genetic variants in the COMT gene affect the speed at which the enzyme works.
- People with fast COMT variants break down neurotransmitters more quickly, while slow COMT increases neurotransmitter levels. These genetic differences can impact attention to detail, working memory, and reaction to stress.
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| COMT | rs4680 | AA | A | 0.48 | GG = higher activity; AG = Intermediate activity; AA = lower activity |
| COMT | rs4633 | TT | T | 0.48 | CC = higher activity; TT = lower COMT activity |
| COMT | rs6267 | GG | T | 0.003 | Minor decrease in COMT |
| COMT | rs165599 | AA | A | 0.64 | Minor decrease in COMT |
| COMT | rs165774 | AG | A | 0.29 | lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment |