COMT
COMT-Gene-1
COMT
Key Takeaways
- The COMT gene encodes a key enzyme for regulating neurotransmitter levels.
- Common genetic variants in the COMT gene affect the speed at which the enzyme works.
- People with fast COMT variants break down neurotransmitters more quickly, while slow COMT increases neurotransmitter levels. These genetic differences can impact attention to detail, working memory, and reaction to stress.
Table 1: My Genetic Variants
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| COMT | rs4680 | AA | A | 0.48 | GG = higher activity; AG = Intermediate activity; AA = lower activity |
| COMT | rs4633 | TT | T | 0.48 | CC = higher activity; TT = lower COMT activity |
| COMT | rs6267 | GG | T | 0.003 | Minor decrease in COMT |
| COMT | rs165599 | AA | A | 0.64 | Minor decrease in COMT |
| COMT | rs165774 | AG | A | 0.29 | lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment |