Resolving inflammation is an active process: The body doesn’t just let inflammation fade away; it actively produces specialized pro-resolving mediators (SPMs) to end inflammation and restore tissue health
SPMs are lipid molecules synthesized from dietary omega-3s—mainly DHA and EPA—which are often lacking in modern diets.
A lack of pro-resolving mediators can allow inflammation to continue, leading to many chronic diseases.
Genetic variants can affect how efficiently your body converts dietary fats into SPMs, meaning some people may need more DHA/EPA or benefit from specific supplement forms.