SPMs
Resolution of Inflammation is an Active Process
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Key Takeaways
- Resolving inflammation is an active process: The body doesn’t just let inflammation fade away; it actively produces specialized pro-resolving mediators (SPMs) to end inflammation and restore tissue health
- SPMs are lipid molecules synthesized from dietary omega-3s—mainly DHA and EPA—which are often lacking in modern diets.
- A lack of pro-resolving mediators can allow inflammation to continue, leading to many chronic diseases.
- Genetic variants can affect how efficiently your body converts dietary fats into SPMs, meaning some people may need more DHA/EPA or benefit from specific supplement forms.