COMT Supplement Interactions
COMT-supplement-interaction
COMT Supplement Interactions
Key Takeaways
- The COMT enzyme can be slow or fast, depending on your genes.
- Some people with slow COMT enzyme function have side effects from methylated vitamins (methylfolate, methylB12), methyl donor supplements, and COMT inhibitor supplements.
- Understanding your COMT SNPs can help you with deciding which supplements may work best for you.
Table 1: My Genetic Variants
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| COMT | rs4680 | AA | A | 0.48 | GG = higher activity; AG = Intermediate activity; AA = lower activity |
| COMT | rs4633 | TT | T | 0.48 | CC = higher activity; TT = lower COMT activity |
| COMT | rs6267 | GG | T | 0.003 | Minor decrease in COMT |
| COMT | rs165599 | AA | A | 0.64 | Minor decrease in COMT |
| COMT | rs165774 | AG | A | 0.29 | lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment |