The COMT enzyme can be slow or fast, depending on your genes.
Some people with slow COMT enzyme function have side effects from methylated vitamins (methylfolate, methylB12), methyl donor supplements, and COMT inhibitor supplements.
Understanding your COMT SNPs can help you with deciding which supplements may work best for you.
Gene
RS ID
Your Genotype
Effect Allele
Effect Allele Frequency
Notes About Effect Allele
COMT
rs4680
AA
A
0.48
GG = higher activity; AG = Intermediate activity; AA = lower activity
COMT
rs4633
TT
T
0.48
CC = higher activity; TT = lower COMT activity
COMT
rs6267
GG
T
0.003
Minor decrease in COMT
COMT
rs165599
AA
A
0.64
Minor decrease in COMT
COMT
rs165774
AG
A
0.29
lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment