TRPM3
TRPM3-chronic-fatigue-migraines-2048x1152
TRPM3
Key Takeaways
- TRPM3 is an ion channel that is sensitive to heat and certain hormones.
- When activated on sensory neurons, TRPM3 sends the signal for pain. In other parts of the body, TRPM3 signaling influences insulin release, immune system function, and blood vessel function.
- Variants in the TRPM3 gene influence pain, cataracts, and susceptibility to ME/CFS.
Table 1: My Genetic Variants
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| TRPM3 | rs262001 | TT | C | 0.17 | altered sphingomyelin levels (sphingomyelin is a phospholipid in the brain’s myelin sheath) |
| TRPM3 | rs10780944 | AA | G | 0.14 | slightly taller on average (males) |
| TRPM3 | rs6560200 | CT | C | 0.51 | C/C: (common genotype) higher risk of ME/CFS |
| TRPM3 | rs1891301 | CT | T | 0.47 | increased relative risk of ME/CFS |
| TRPM3 | rs11142508 | CT | C | 0.41 | increased relative risk of ME/CFS |
| TRPM3 | rs1160742 | GG | A | 0.44 | increased relative risk of ME/CFS |
| TRPM3 | rs1328153 | AG | G | 0.20 | increased relative risk of ME/CFS |
| TRPM3 | rs7865858 | AG | A | 0.40 | increased relative risk of ME/CFS |