HLA-B27: Genetic Variant That Increases Susceptibility to Autoimmune Diseases
HLA-B27-2048x1152
HLA-B27
Key Takeaways
- The HLA-B27 serotype is linked to an increased risk of several autoimmune diseases, including ankylosing spondylitis, psoriatic arthritis, and IBD.
- Not everyone with HLA-B27 develops disease; environmental and other genetic factors also play a role.
- You can check your 23 and Me or AncestryDNA raw data for the HLA-B27 genotype.
Table 1: My Genetic Variants
| Gene | RS ID | Your Genotype | Effect Allele | Effect Allele Frequency | Notes About Effect Allele |
|---|---|---|---|---|---|
| HLA | rs4349859 | GG | A | 0.02 | Higher likelihood of carrying HLA-B27 |
| Inter-gen | rs13202464 | AA | G | 0.07 | Higher likelihood of carrying HLA-B27 |