Key Takeaways

Sjögren’s disease (Sjögren’s syndrome) is an autoimmune disorder affecting 1% of the population, which attacks specific proteins produced in the body.
The first symptoms are usually dry eyes and dry mouth.[ref]
Genetic variants can increase susceptibility to Sjogren’s — and can point towards natural solutions that may help.

Your Genes

Gene	RS ID	Your Genotype	Notes for Your Genotype	Effect allele	Effect allele frequency
HLA-DRB1	rs2187668	CC	typical	T	0.11
HLA-DRA	rs3135394	AA	typical	G	0.10
HLA-DQB1	rs3129716	TT	typical	C	0.11
HLA-DQA1	rs9271588	CT	half the normal risk of Sjögren’s (protective)	T	0.46
IRF5	rs4728142	GG	typical	A	0.42
IRF5	rs10954213	GG	slightly decreased risk of Sjögren’s	A	0.59
IL12A	rs485497	AA	slightly increased risk of Sjögren’s	A	0.49
TNIP1	rs6579837	GG	typical	T	0.09
STAT4	rs10168266	CC	typical	T	0.19
STAT4	rs11889341	CC	typical	T	0.22
OAS1	rs10774671	AA	typical	G	0.36
OAS1	rs117026326	CC	typical	T	0.01
TNFAIP3	rs2230926	TT	typical	G	0.05
TNF	rs1800629	GG	typical	A	0.15