- 10.1038/s42255-019-0105-0
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Research Article
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- Comparison of hypoxia- and hyperoxia-induced alteration of epigene expression pattern in lungs of Pleurodeles waltl and Mus musculus
? et al. ?
Research Article
10.1371/journal.pone.0299661
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- Cellular adaptation to hypoxia through HIFs and beyond
? et al. ?
Research Article
- "Importantly, changes in O2 can also be sensed via other stress pathways as well as changes in metabolite levels and the generation of reactive oxygen species (ROS) by mitochondria."
- "Collectively, this leads to cellular adaptations of protein synthesis, energy metabolism, mitochondrial respiration, lipid and carbon metabolism as well as nutrient acquisition. "
- Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models
? et al. ?
Research Article
- "Animal models in vivo fail to recapitulate some of the key hallmarks of human physiology, which leads to human cell cultures; however, they are prone to bias, namely when pericellular oxygen concentration (partial pressure) does not respect oxygen dynamics in vivo."
- "Therefore, in this review, we present evidence mandating for the close control of oxygen levels in cell culture models of hypoxia."