Articles

Transgenerational adaptation to hypoxia Kim et al. 2025 Research Article 10.1126/sciadv.adv9451

"We found that parental hypoxia exposure increased P0 longevity, caused intergenerational lipid reduction, and elicited transgenerational fertility reduction that was dependent on generationally transmitted small RNAs."

"Here, we find that Caenorhabditis elegans adapt to repeated generational stresses. We show that, upon two repeated generational hypoxia exposures, the life-span extension is eliminated, and after four repeated generational hypoxia exposures, the reduced fertility is eliminated."

"Transgenerational hypoxia adaptation is dependent on the H3K27 trimethyltransferase PRC2 complex, and we identified transgenerationally adapted genes."

"Our findings reveal that transgenerational adaptation occurs and suggest that H3K27me3 is a critical modification for adapting to repeated generational stresses."

Genetic analysis of hypoxia signaling and response in C elegans Shen et al. 2003 Research Article

"Here, we briefly review the characterization of C. elegans hif-1 and interacting genes, and discuss genetic strategies for studying hypoxia signaling and response."

Hypoxia signaling and resistance in C. elegans Powell-Coffman 2010 Author Manuscript

"This review provides an overview of C. elegans responses to hypoxia, ranging from adaptation and arrest to death, and highlights some of the recent studies that have provided important insights into hypoxia signaling and resistance."