Terminology

Transgenerational Epigenetic Inheritance (TEI)

The transmission of epigenetic gene regulatory information across generations.

Review Articles

Epigenetic Mechanisms of Genomic Imprinting: Common Themes in the Regulation of Imprinted Regions in Mammals, Plants, and Insects Macdonald 2012 Review Article

"Genomic imprinting is a form of epigenetic inheritance whereby the regulation of a gene or chromosomal region is dependent on the sex of the transmitting parent. During gametogenesis, imprinted regions of DNA are differentially marked in accordance to the sex of the parent, resulting in parent-specific expression."

"This review examines some examples of the epigenetic mechanisms responsible for genomic imprinting in mammals, plants, and insects."

Research Articles

From Correlation to Causation: The New Frontier of Transgenerational Epigenetic Inheritance et al. Article

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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans et al. Article

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Author Manuscripts

Intergenerational Transmission of Gene Regulatory Information in Caenorhabditis elegans Minkina et al. 2019 Author Manuscript

"The nematode Caenorhabditis elegans has been particularly instrumental in the effort to understand TEI, as multiple environmental and genetic triggers can initiate an epigenetic signal that can alter the expression of both transgenes and endogenous loci."

Epigenetic dynamics during germline development: insights from Drosophila and C. elegans Gleason et al. 2024 Author Manuscript

"Seminal work in both Drosophila and C. elegans has elucidated the role of various regulators of epigenetic inheritance including (1) histones (2) histone modifying enzymes, and (3) small RNA (sRNA)-dependent epigenetic regulation in the maintenance of germline identity."

"This review highlights recent discoveries of epigenetic regulation during the step-wise changes of transcription and chromatin structure that takes place during germline stem cell self-renewal, maintenance of germline identity, and intergenerational epigenetic inheritance."

Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans Chey et al. 2023 Author Manuscript 10.1016/j.tig.2021.08.011

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