Terminology

Lysine Lactylation (Kla): A post‑translational modification linking cellular metabolism to epigenetic and signaling pathways.; This process is regulated by a range of enzymes and metabolites, including lactate.

Review Articles

Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets Peng et al. 2025 Review Article: "Beyond chromatin, [lactylation] has also been identified in a growing number of non‑histone proteins, ... such as AARS1‑K120la, ACSS2‑Kla, MRE11‑K673la, NBS1 K388la and GNAT13‑Kla has illuminated novel regulatory mechanisms and reinforced the potential of non‑histone [lactylation] as a promising avenue for research."; "In this review, we systematically summarize the molecular mechanisms, biological functions, disease associations, and therapeutic implications of both histone and non‑histone [lactylation]."

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies ??? et al. ??? Highlight: ?
Lactylation: From Molecular Insights to Disease Relevance ??? et al. ??? Highlight: ?
Lactylation: novel epigenetic regulatory and therapeutic opportunities ??? et al. ??? Highlight: ?
Lactylation: The emerging frontier in post-translational modification ??? et al. ??? Highlight: ?