Terminology

Rad50

A protein involved in DNA double-strand break repair.

Rad50 is a member of the structural maintenance of chromosomes (SMC) family of proteins.

This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast).

• This MRN complex (MRX complex in yeast) binds to broken DNA ends and displays numerous enzymatic activities that are required for double-strand break repair by nonhomologous end-joining or homologous recombination.

Research Articles

A Single-Nucleus Atlas of Seed-to-Seed Development in Arabidopsis Lee et al. 2023 Preprint Research Article

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Developmental patterning of sub-epidermal cells in the outer integument of Arabidopsis seeds Fiume et al. 2017 Research Article

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NBS1 plays a synergistic role with telomerase in the maintenance of telomeres in Arabidopsis thaliana Najdekrova et al. 2012 Research Article

"We used Arabidopsis thaliana to study the possible functions of the DNA repair subunit, NBS1, in telomere homeostasis using knockout nbs1 mutants."

"The results showed that although NBS1-deficient plants were viable, lacked any sign of developmental aberration and produced fertile seeds through many generations upon self-fertilisation, plants also missing the functional telomerase (double mutants), rapidly, within three generations, displayed severe developmental defects."

"Cytogenetic inspection of cycling somatic cells revealed a very early onset of massive genome instability."

"Molecular methods used for examining the length of telomeres in double homozygous mutants detected much faster telomere shortening than in plants deficient in telomerase gene alone."

Homologous recombination in planta is stimulated in the absence of Rad50 Gherbi et al. 2001 Research Article

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