Sounds good. Well, thank you everybody for joining. I'm so glad that Mondays work. Well, this is, uh, this is a, a new insight for us.

Um, you know, most of the conditions that we deal with have some component of the immune system involved, right?

So we think about most chronic conditions, so heart disease, diabetes, Alzheimer's, uh, you know, Parkinson's, dementia going into the cancers area.

Um, and then of course there are very frank immune related issues like autoimmune conditions, allergies, asthma, infections, all of these things.

All of these conditions involve the immune system in one way or the other. Whether the immune system, if it's not the cause,

if it's not the primary cause of the condition, it's certainly driving the condition or it's creating risk for the condition, right?

So if you think about, for example, with heart disease, um, what's, what seems to be pretty clear is that inflammation from the immune system

and immune related functionality is a major risk driver. Same thing with type two diabetes. Um, you know, there's, there's, uh, hyperinsulinemia,

hyperglycemia and so on, but inflammation also seems to be a driver. Alzheimer's, Parkinson's, same thing, right? And we look at virtually every cancer there is.

The immune system is playing a role in that. Uh, and then all the way to, to, uh, you know, more common,

but less severe things like allergies, asthma, food intolerances, eczema, psoriasis and all that. We know that virtually everyone knows

or is dealing with these types of conditions, right? And these are all chronic inflammatory conditions. Um, and some of them may pop up

as like mysterious sensitivities, things that just don't make sense. Where you used to be able to eat this and deal with this

and wear that, and now all of a sudden you can't, it creates rashes and things like that. You're not at all alone.

We hear this all the time, and it impacts millions of people today. And so often people think about the immune system when they

have just specific immune dysfunctions, or they're thinking about it as a defense mechanism only when, when it's cold and flu time.

But what I really want to emphasize today is the, is the importance of thinking about the immune system all the time

because it is present and, and, uh, prevailing and functioning in virtually every chronic condition we face, including obesity and everything else, right?

Um, so we want to really answer the question of why this is happening. Why are we getting so much immune dysfunction,

whether it's chronic low grade inflammation leading to heart disease and diabetes and Alzheimer's and so on, or it's allergies, asthma, autoimmune disease

where your immune system's attacking the wrong things and attacking your own tissues. What is happening and how is the immune system supposed

to function, right? What is the relationship between the immune system and the microbiome that allows the immune system to function properly without creating all the

havoc that it can create? So we, we really wanna understand this disruption, right? What is disrupting the balance at a slightly deeper level?

And then of course, we'll talk about some solutions as well. So the goal for today, explore the profound link

between the microbiome and the immune system. Understand how the microbial imbalance can be the root cause of immune dysfunction.

So we'll describe those relationships and the mechanisms there. And then discover foundational strategies to begin restoring balance from inside and out, right?

So we want to be able to take action and improve our systems. So your gut immune sy your gut is

the immune system's headquarters. In many ways, it's the eyes and ears of your immune system, which I'll emphasize again,

uh, but considering that we are holobiome, right? So we are a complex ecosystem where we have thousands of different species that all live together

and have to work together in, in order to perpetuate the health of the whole. This is what a holobiome is. It's a super organism.

And so our ecosystem is made up of microbes, all types of microbes and our own cells, and then our microbes

and our own cells have to communicate and function together to protect the entire host, which is us, the human right.

And this is very true of the immune system. The immune system has a very intimate relationship and a dependent relationship on the microbiome,

which you'll get to see, uh, the mucosa is this massive, vast area of our internal system, right? So you think about the gut mucosa, how large

that is our respiratory mucosa. So everything in our, from our nasal passages, our sinuses, um, you know, down our breathing tubes into our lungs

and so on, our urogenital mucosa, everything that enters could and does enter into the urogenital tract. Um, virtually every part of the inside

of the body has a mucosal barrier to it. And most things that enter the body will enter through a mucosal system.

This whole mucosal system is almost 4,000 square feet, um, in, in surface areas. So think about the size of that, right?

Uh, for those of you in the metric system, that's something like 300 to 400 square meters. So it's a very large size.

It's a, it's a large, uh, apartment. Everyone will be happy with an apartment that size. And so it's a massive surface area,

and it's completely covered with microbes. 70 to 80% of your immune system resides as part of this mucosa. And in the gut, it's, it resides as part

of the gut associated lymphoid tissue, right? So it's this lymphatic tissue, meaning it's immune tissue lining the gut, especially the small intestine,

and it has a mucosa, uh, on top of it as well. So it's got a, this mucus layer and that mucus layer is very dynamic.

There's a lot of structural elements in that mucus layer. And of course, it's, there's, there's trillions and trillions of microbes that live there as well.

And your immune system plays in that mucus layer in order to understand what's happening with the world around you.

And I promise you, we'll dig deeper into that. So it's the largest sampling site in the gut, right? So the gut has all of this immune tissue,

because virtually everything that enters the body, unless it's entering deep through the skin or through through some sort of trauma, an unusual way

of entering the body, normally it enters through the gut and through the gut mucosa. So if you think about the things you eat, the things you,

Dr uh, you drink, you breathe in, everything that you breathe in that are particles and microbes and all that gets captured

by your mucus in your respiratory tract, and then that mucus gets sent down into your throat, you end up swallowing it.

If things go in your ears, it'll drain into your eustachian tube, which goes to the back of your throat.

If things go into your eyes, it'll also drain down to the back of your throat. So virtually everything goes into your mouth.

Now, humans also have this, uh, crazy habit of touching their mouth and their face, you know, hundreds upon hundreds of times throughout the day.

So everything we touch physically as well ends up somehow into our digestive tract. So it becomes a largest sampling site for your immune system

to sample and understand what the environment looks like that you are existing in, right? The immune system doesn't have any outward

facing components. There's nothing on your, uh, your epidermis layer. There's nothing on your scalp, there's nothing in your, uh,

on your face, on the surface of your skin where your immune system can detect and sense everything in your environment.

So it has to wait for things to come into your digestive tract. And in the digestive tract is where it samples

what is in your environment, right? That's how it learns. Whether you are here like me in, in the suburbs of Chicago,

or you're like in Michael, like you're in Italy somewhere, or you're in California, or you're anywhere else, the, the antigens change.

The threats change, uh, but your immune system has to be able to detect those changes and then adapt to it.

And it does so through sampling in the gut, right? This is why evolutionarily, we have so much of our sampling tissue in the gut.

So the conversation between, uh, the, um, the microbes and the immune system. So when you think about that mucosal tissue, right?

That mucosal tissue is over 4,000 square feet. That's a massive surface area. It's covered with 30 to 40 trillion microbes

that dot the vast majority of the, uh, of the mucosal tissue. And in the mucosal tissue, you also have a number

of different types of immune cells. Uh, one of the types of cells are, are sentinel cells, and these are cells that patrol the immune, uh, the,

the mucus, uh, area looking for dysfunctional microbes, you know, potentially invading pathogens like viruses, bacteria, toxins, and so on.

These are largely dendritic cells. And then you have natural killer cells, you have macrophages that can also eat stuff up,

but dendritic cells are the main player here, right? Because dendritic cells are constantly sampling things and consuming them and then presenting them to lymph nodes.

And then decisions are being made in those lymph nodes, whether or not that that's a thing that the immune system needs to pay attention to

and needs to attack. So, dendritic sites are called, or dendritic cells are called dendritic cells because they have these dendrites, they have these tentacles

that can reach around from the other side of the gut lining, for example, across the, the intestinal barrier into the intestinal mucosa,

and grab things like bacteria and viruses and food particles and so on. And it's constantly sampling things right? To present to the immune system

to see if the immune system thinks it should respond to it. Now, keep in mind that there's about a 200,000 to one ratio

of microbes to these dendritic cells, right? So the dendritic cells have a very hard time patrolling this massive surface area

because there's 200,000 times more microbes in that area than dendritic cells. And so the microbes, some of them may be harmful or pathogenic.

So then what is the likelihood that the dendritic cells, uh, grab happen to grab a pathogenic microbe to sample it in order to present it

to the immune system, right? So the, the chances of that can be much lower than you want it, because you want, when a pathogen enters the system

for your immune system to detect it immediately, but this 200,000 to one ratio makes that a little bit harder

because it's a lot of sampling in order to hit the right microbes and the right viruses and so on, that may be a potential issue.

As a result of that, there's this constant signaling and communication between the commensal microbes. So microbes that mean you no harm

that live within your system as part of you as part of the holobiome and the immune system to try to get the immune system

to understand what is friend or what is foe. That 200,000 to one ratio is difficult to manage unless all of those microbes

also are on your side also acting as eyes and ears of the system in order to be able to detect a change in the mucosa,

meaning an infectious virus or an infectious bacteria or a toxin comes in, right? So the, the analogy I always give to make

that understandable to people is that imagine you had a, a, a, you know, music festival in an enclosed stadium, right?

And that stadium had 200,000 people in it. You are the one and only loan security guard in that entire stadium.

And your job is to find the two or three people among the 200,000 that actually mean harm to the rest of the people, right?

They, they, they're gonna do something bad in that area, but they look very much like everyone else. Uh, how do you go about finding them right?

Within that period of time that the concert is happening? You can go and tap each individual on the shoulder one

by one and examine them and check them for, for, um, you know, deleterious objects and so on. But that likely won't happen within the con uh, constraints

of the time, uh, that the concert's happening, and people can move around and shift, uh, shift seats and things like that.

So it becomes hard to keep track of who you've seen and you who you haven't seen. Now, the only way you could effectively patrol

that entire space is if the other 197,997 people are also on your side. They're also wired to you, meaning anything they see

that's suspicious where they may be, they can send out a signal to call you to that area, right? That's a, a reasonable way to do it.

So it's a bit of a neighborhood watch mentality, and that's exactly what's happening between your immune cells and your commensal bacteria.

Your commensal bacteria often act as the eyes and ears for your immune cells because it, it's too much surface area,

too many microbes in the region for your immune cells to constantly patrol and find everything that may be harmful.

So it counts on your commensals to look for things and notice differences that are harmful and then signal to your immune system to show up to

that area, right? This is in a very important crosstalk. There's a number of, of co compounds that are used for this.

So cytokines, which can be inflammatory cytokines, uh, short chain fatty acids, uh, interleukins, and other chemicals that the microbes in the region can use

to alert the immune system to show up there, right? So this crosstalk is critically important for your immune system to function.

So microbes, as I mentioned, act as a ear, eyes and ears of the system. And then specific bacterial components can activate certain

receptors that the immune system recognizes, right? And these are receptors that are either on the immune cells itself or in epi epithelial cells or barrier cells and so on.

And the activation of these receptors activates an entire immune response to that area. So this, uh, microbiome immune crosstalk, this conversation

that they have is incredibly important. Now, this conversation also goes to the tolerance phase, which I'll talk about in a moment,

but just keep that in mind and let that absorb in for a second. That your immune system requires the microbiome

to be the eyes and ears of the system. 'cause the system is too densely populated, it's too large in surface area for your immune system

to adequately patrol every square inch of your insides, every minute of every day, right? So it counts on the immune sys, uh, on the microbiome.

And if the microbiome is not playing nice, and the microbiome is not willing to re to alert your immune system, it makes you

as the host much more susceptible to things coming in and having adequate amount of time to infect, cause toxicity

and so on, right? That is the big difference between somebody that gets exposed to a virus and then gets sick

and clears it within three or four days versus somebody to get ex exposed to that same virus. Maybe it takes a few more days for them to actually start

to feel the symptoms of getting sick, but then they get sick for seven, eight days instead of three or four, right?

A big difference between those two individuals is the one individual had a healthier microbiome. So the microbiome recruited the immune system to

that area much faster. So a smaller viral load was allowed to build versus this individual over here where it takes longer for the immune system

to detect the presence of the virus because the commensals aren't being so cooperative. So then the virus has more time to replicate

and create a bigger viral load. Then when the immune system does finally respond, the viral load is bigger, the person will feel sicker,

the immune system is gonna be much more aggressive and, and go after it with a lot more tools making you, uh,

creating a prolonging effect of the illness, right? So that's a really important distinction. So it helps you understand how your immune system actually functions at the core.

And obviously, one of the most important things for your immune system to function is a healthy microbiome. And we'll talk about what that looks like as well.

Now, the, the microbiome also trains the immune system. And this is a very, very important part, right? So the immune cells are born naive, right?

The immune cells are either born in your bone marrow or in your thymus gland when they're born, all the immune cells are virtually the same.

They have the same information, right? Keep in mind, the immune system is a system that needs to adapt to changing environments, changing seasons,

you know, changing people around you. So your immune system cannot be born with all the knowledge that it needs to figure out who to fight

and who not to fight, because the targets change constantly, right? Um, if, if we don't want our immune system attacking food,

which we don't want, we don't eat the same things every day of every year for the rest of our lives,

we change our diets quite a bit, right? From time when we're babies to toddlers, to adolescents, to adulthood, we've changed what we eat frequently,

how we eat it, when we eat it, the source of the food and so on. So there's no way for the immune cells to have all

of this knowledge of what all of this possible food could be. In order to understand that it should not be attacking it.

The only way the system functions is if the immune system is able to adapt to a changing source of food that's coming in.

And the way it does that is it, it gets trained by the microbiome, right? Remember, microbes are much faster to adapt, much faster

to evolve than human cells are. And as a result of that, the microbes in the region can adapt to changing environments much faster.

And as a result, it can train the immune system to say, Hey, this is normal food. You don't need to attack this.

And it helps dampen that process. And I'll talk about that a little bit more detail of how that actually happens.

So, microbial signals are essential for the proper development and function of immune tissue. So immune cells are bone naive.

They have, they have capabilities, meaning they've got the weapons, uh, they've got the weaponry systems, right? They've got the super oxides, the complement systems,

the antibody production capability and so on, but they don't have the intelligence to know what to attack and what not to attack.

So that training and that development comes from the microbiome. So the microbes teach your immune system what to attack in terms of pathogens, toxins, and so on,

and what to tolerate. Now, commensal microbes also help train these immune cells. A a lot of times in the lymph nodes itself, it can train it

or in the mucosa, um, where, where it can, it can help with activating these immune cells to respond to things like viruses that are detected, right?

And that activation by the microbiome is part of its training going, okay, next time you see this virus that I activated you for, know that you need

to attack it, right? And the microbiome also can suppress unwanted immune responses, which is a lesson to the immune system that, Hey,

next time you see this food particle, don't attack it. Right? That is, that is this, uh, um, uh, training system

that the microbiome offers to the immune system. This training system leads to something called oral tolerance, right? Which is the key to immune piece.

So oral tolerance relies on your immune system to actively learn to remain unresponsive to things that do not cause harm to the host, right?

So things like foods and environmental tox, uh, environmental particles, not environmental toxins, but particles like ragweed and dandelion and, and, uh, you know, pollen and so on.

And of course, ultimately your own tissue as well. You don't want it attacking your own tissue. And this is crucial for preventing things like allergies,

uh, you know, food sensitivities, environmental sensitivities, autoimmunity, and so on. And, and given that we live in a world of continuously, um,

you know, dysfunctional guts, it's no surprise that all of these types of conditions continue to skyrocket, right? Allergies are getting worse and worse every year,

and they're impacting more and more people. And at younger and younger ages, you know, it's, it's, we're facing virtually an epidemic of, uh, allergies

and asthma among kids. I think we've got over 10 million US kids that have allergies and asthma. We've got, uh, millions of people with food sensitivities

that now have to eat a very restricted and narrow diet. And of course, autoimmune conditions become more and more prevalent as each year passes.

Um, you know, something like 35, 40 years ago, we had less than 40 known autoimmune conditions. Now we have over 110.

So we've created new conditions, new diseases that we have to deal with, um, and that's, I think a lot of it is due

to continuous dysfunction in the gut microbiome. And as your gut microbiome becomes more and more dysfunctional, all of these immune susceptibilities become more

and more prevalent as well. So it requires, uh, a healthy gut microbiome. And then the oral tolerance component also really is

dependent on a healthy gut lining, right? You cannot have a severely leaky gut and allow and, and then expect the tolerance function

of the immune system to work. When your gut is leaky, you already have a dysfunctional barrier, and a lot of the sampling occurs at the

barrier of the intestines. So without a proper barrier, the antigens antigen sampling becomes corrupted. Uh, you also need a diverse, uh, microbiome

because a diverse microbiome is what helps signal the right things to the immune system, and then, um, suppress unfavorable immune responses.

And then also, um, helps recruit the immune system where it needs to be recruited, but also prevent the recruitment

and the activation where we don't need it, right? Diversity in the microbiome is one of the most important things when it comes

to this type of immune function. So let's look at the peacekeeper and the different alarms that we have within the system.

The first one is secretory iga. This is kind of a peacekeeper tool within the immune system, because they are antibodies, they are not super

specific to antigens, meaning they can bind lots of different types of antigens they're found coded in the mucosal surfaces, including things like your, uh, tear ducts

and your, your tears, your saliva, and all the mucosal surfaces. The whole idea is to neutralize threats by binding to them,

whether it's a bacteria, a virus, a toxin, or what it may be, and then doing so without activating other cascades of the immune system,

which tends to bring inflammation, right? So secretory IGA A is wonderful because it can, um, it can jump onto something

that's potentially problematic, neutralize its effect without activating a bunch of inflammatory responses. So, so this is then clearly in the literature boosted

by a healthy microbiome, right? There are some supplements you can take that I'll mention, uh, you know, uh, later on as well to help boost it.

But a healthy microbiome is one of the key components of boosting secretory iga. A IgE, which many of you are probably too familiar with, uh,

is an antibody driving allergic hypersensitivity reaction, right? This is the fire alarm everywhere that occurs. And, and overproduction, uh, and,

and, sorry, it's overproduced, uh, IgE, when IGA function is impaired. So if you have a dysfunctional gut microbiome, you're not producing enough IGA as a result of that,

your immune cells try to make up for that by producing more IgE, right? And so what tends to happen then is your first line

of defense in your mucosa becomes IgE. And IgE is a, um, is a marker or a, an, uh, immunoglobulin

that triggers an inflammatory response. So instead of a food particle coming in, getting coated with IGA, and then it's neutral,

it doesn't really cause any problems, doesn't create inflammation. That same food particle will come in, gets coated with IgE,

and as a result, that food, that food particle creates this massive trigger of inflammation in the system, right? And I think many people, you know, experience this condition

as like mast cell activation syndrome or histamine intolerance and so on. Those are all components of this, uh, overt IgE alarm.

And then we have these really, really important cells called regulatory T cells, right? We can think of 'em as the diplomats

because they're, they're crucial for maintaining tolerance and suppressing excessive or inappropriate immune responses, right? Um, so these cells are the cells that can teach

the immune cells not to respond to certain things. It can do it in the mucosa, it can do it in the lymph nodes,

it does it throughout the circulation, it does it anywhere. There's immune response going on. It's monitoring those immune responses.

And if it's an unfavorable immune responses, meaning it's, it's targeting your own tissue, it's targeting a food particle, an environmental particle,

or even a, a, a bacteria, a virus that's commensal, it can suppress that immune response and then teach those immune cells that, hey, you don't need

to do that response. That is a tolerant, that's something we should be tolerant to. Now, these tregs are, are largely driven in terms

of their function by a diverse gut microbiome, especially species like, uh, fecal bacteria, prosci, various types of, uh, clostridia,

and then the, the spore based probiotics as well. So we need a healthy immune, uh, healthy microbiome in order

for the regulatory T cells to function the way they're supposed to. So now you can imagine what, what tends to happen, right?

As your microbiome becomes dysfunctional, less diverse, you, you end up growing too many pathos or pathogens within your microbiome.

You're starting to produce less secretory iga. Your microbiome is then not signaling early enough if there's a presence of an infectious agent, like a virus

or a bacteria, and on top of that, your t regulatory cells aren't functioning properly and you have too much IgE production going on.

So that leads very simply to things like allergies, asthma, and so on, all the way to autoimmune conditions. But to, to put it in practical sense,

what's happening is antigens are still en entering your body. And antigens, for those of you that aren't familiar, are basically any compound

that can trigger an immune response, right? So antigens are entering the system. They're being encountered by IgE, which means it's more

of a fire alarm. Lots of, uh, immune reactive cells show up the innate immune reactive cells. They're pumping a lot of inflammatory

or pro-inflammatory mediators in that space. So now you're getting inflamed and tired and red and rashes and all of this stuff that occurs in these responses.

And at the same time, the regulatory T cells aren't functioning well enough to suppress all of this immune reaction, right?

Which means that your immune system continuously gets trained to react in this inflammatory manner to everything, right? So you can see, just looking at this slider around,

you can start to see and understand how a dysfunctional gut microbiome can throw off, how the immune system is supposed to function,

and it can create all of these sensitivities and issues. And then the final piece that's really important is this leaky gut issue.

When you are dysbiotic and you have low diversity, it's much, you are at a much higher risk of developing leaky gut.

And the problem with leaky gut is it creates a break in that mucosa. And as a result, you get tons of microbes flow, uh,

you know, flowing into the inner parts of the lining of the body, uh, like the basal lateral circulation, or in circulation itself,

or in the lymphatic system and so on. And that creates massive amounts of inflammation throughout the body. That inflammation can have a real hindering effect on

how the immune system is supposed to function. So leaky gut is another massive driver of immune dysfunction, right? And leaky gut is at the root, uh, uh, as a risk factor

for lots of different immune conditions, including autoimmune conditions. And so a dysbiotic gut not only reduces secretory IgE production,

increases IgE production, and then as we showed here, also, uh, reduces regulatory T cell function, and at the same time, drives massive amounts

of chronic low grade inflammation, uh, and creates a crosstalk issue between the microbes and the immune system. 'cause now the immune system's running

around haywire, right? So leaky gut is a big problem. This is a damage to the mucosa and broken tight junctions.

And of course, that allows things like, uh, food particles and environmental fragments and all that to pass through. So it increases the number of targets

that the immune system now has to go after. Uh, it's the, a key driver of leaky gut is stress.

Poor diet, we'll talk about diet a little bit, toxins, antibody use, uh, and certainly overuse of, uh, sorry, not antibody,

antibiotics, overuse of antibiotics, and then infections and other dysbiosis, uh, drivers as well. So including things like exposure to, you know, uh, plastics

and chemicals and so on. We'll put all of that within the, the category of toxins. Uh, and then a result, as I mentioned,

it triggers chronic inflammatory and systemic inflammatory responses as well. Uh, and then at the end of the day, the, uh, the effect of,

of leaky gut, uh, which I'll point out here, is the translocation of, um, LPS lipopolysaccharide, right? Which comes from gram-negative bacteria in your gut,

and which is perfectly fine for it to be produced, uh, in the gut. Now, in, in people with small gut,

small bowel dysfunction like sibo, you tend to have way too many gram-negative bacteria than what's naturally there. So you end up with more LPS

and more that can leak through the lining of the gut. And so LPS ends up in the liver or in circulation, which is where it creates this issue

of endotoxemia, which can drive systemic inflammation, right? So we see here metabolic endotoxemia, uh, it activates inflammatory pathways by activating toll-like receptors.

A lot of this can come from lifestyle choices. So eating highly processed foods, very sugary and, um, sweet foods,

and of course foods that have pesticides, herbicides, and antimicrobials and all that in there. Uh, it can also create a, um, uh,

macro macrophage infiltration into fat cells, uh, releasing more free fatty acids, which becomes a big problem for metabolic syndrome.

Uh, and then also it can drive hyperglycemia. So it can increase the risk for things like, uh, diabetes, right?

So you've got now chronic low grade inflammation, potential risk for diabetes or blood sugar management, and then a, um, an issue with lipolysis

or swelling even of fat cells. But, uh, unusual re, uh, release of free fatty acids that can be very inflammatory,

can damage arteries and so on. So there's a lot that tends to happen here, uh, with the, with the result of endotoxemia.

And all of that comes back to a healthy, diverse gut and maintaining the barrier system of the gut, right?

So when we look at immune, uh, immune overreaction, so things like sensitivities, histamine intolerance, uh, uh, MCAS or MCAS, we end up having leaky gut

and lo loss of oral tolerance as a key component of all of these categories of dysfunction, right? You have to have leaky gut and loss of oral tolerance,

and loss of all tolerance follows leaky gut, because leaky gut is di uh, is driven by a dysbiotic or dysfunctional gut microbiome.

And the dysbiotic or dysfunctional gut microbiome, uh, then leads to a barrier dysfunction as well in individuals, right? So, uh, that becomes an interesting thing to,

to keep in mind, is that leaky gut is likely behind most of these dysfunctions. But what starts leaky gut is this dysbiosis

that we talked about, and we'll talk about how to fix the dysbiosis as well. And this issue here, uh,

manifests itself like food sensitivities, histamine intolerance, mast cell activation syndrome, uh, and then other signs and symptoms that other people may notice is

digestive upset, right? So, bloating, intolerance, gurgling in the gut all the time, skin reactions, uh, things like eczema, um, flushing,

rashes, uh, you know, psoriasis and so on. Uh, all can be driven by this. And then there's headaches and migraines that people tend to get.

Brain fog, um, you know, chronic fatigue, nasal congestion, all of these things are part of the symptomology of leaky gut.

Um, which, you know, most people have leaky gut. We've, we've tested, we've done clinical trials, and over 55% of healthy individuals

that don't have any medical conditions, have not been treated for any medical conditions and so on. 55% of them have leaky gut, let alone anyone

that has had symptomology. Uh, and that symptomology can be defined with the number of these things here. Um, I would, I would estimate it's 85

and 90% of the adults, uh, that we see, uh, that, that are in the western world that have leaky gut.

And then of course, leaky gut can lead to chronic low grade inflammation. Uh, and it can be an environmental trigger as well,

ultimately leading to autoimmune conditions. But here's a really important thing to think about autoimmune conditions as a triad here.

And you need every component of that triad in order to initiate an autoimmune response. Number one, uh, people, most people suffer from autoimmunity tend

to have a genetic predisposition towards it. But the predisposition doesn't mean you're gonna develop it. You still need these other two components,

an environmental factor and dysbiosis and or leaky gut, right? So what we can, uh, what we can see then is that, um,

the environmental factor can be, um, things like, uh, exposure to toxins, uh, round of antibiotics, a really stressful month

or week, you know, lots of travel, things like that. Um, dietary, uh, dysfunction. So all of a sudden you're like, I'm not paying attention

to my diet anymore, and eating whatever you want, fried foods, high caloric foods, high sugar foods, and so on.

That can also be an environmental trigger or factor that, that allows the dysbiotic gut microbiome to create chronic low grade inflammation, right?

And then it creates something called the bystander effect. And the bystander effect is important to remember because a bystander effect, um, is, is one that, uh,

allows your own tissue to get accidentally presented to the lymph nodes as the culprit. Um, and when it gets accidentally presented as a culprit,

then your immune system continues to make antibodies and other immune defenses against your own protein. This is happening in the melee of, of an, IM of an, uh,

of an immune response, uh, to, let's say a virus or bacteria toxin. There's a lot of damage occurring there,

including your own tissue. And sometimes these dendritic cells accidentally pick up your own tissue and present it to the immune system.

But remember from before, that's an unfavorable response. And so the microbiome can upregulate the treg cells to stop that response, right?

But if your microbiome is unhealthy, you're gonna be driven into this accidental bystander effect, uh, which can then lead to, uh,

autoimmune conditions and so on. Now, also, keep in mind that autoimmune conditions are things like Hashimoto's thyroiditis, rheumatoid arthritis, IBD type one diabetes

and so on, allergies and asthma, right? Often linked to loss of oral tolerance, impact GA, uh, impaired and impacted IGA function, uh,

th two IgE dominance. So then your system leans towards the IgE side to make up for loss of iga, uh, which means that it starts to react

to everything in an allergic manner, right? We also have the gut lung axis where gut microbes, um, that are in the lungs can impact lung immunity,

where these gut microbes can actually signal to the gut mic, the lung microbes signal to the gut microbes that there's a problem going on in the lungs,

and that they need to recruit immune cells so that region, the gut microbes and help recruit immune cells to the lungs.

That's one of the ways in which our body deals with respiratory infections. Um, and that's why actually in covid, people

who had the most dysbiosis within their gut microbiome had far worse outcomes with the exposure to the virus, uh,

compared to individuals that had a healthy microbiome. So, um, for example, someone who was diabetic, let's say there were 45

and diabetic, uh, compared to another 45-year-old who is not diabetic. The diabetic 45-year-old had a tenfold increase, 10 x increase in having a severe response to the virus,

meaning hospitalization and or death. And the big difference between the two is that diabetic will have a significantly disrupted gut

microbiome and a lot of the receptor sites for activating the immune response and all that become compromised in diabetes as well.

But it's the dysfunctional gut microbiome. That's the biggest lever and biggest trigger. And then following up to that, university college Cork did a number of studies

where they were able to profile the microbiome of somebody that is dysbiotic and has high patho. So these are pathogenic organisms that are

opportunistic in some cases and not in others. And people with high levels of those microbes always had a really severe response to covid, uh,

and potential hospitalization and even death, um, all because their microbiome was not diverse, right? And so the same thing happens with allergies,

asthma, and so on. Your microbiome's attacking things that it shouldn't attack, and you don't have adequate IgE to neutralize those things.

You're pushing an IgE response, which is a hypersensitive response. And because your microbiome's dysfunctional, you also don't have your treg cells

functioning properly, right? So we talked about the lungs, and this is, uh, an important illustration of everything that occurs in the immune response, right?

So you have the early innate responses are the fasts first responders. They're just gonna show up and blow torch everything in a given area, right?

They're gonna, um, you know, basically nuke the area, if you will, because they don't know who the specific target is.

They just know that there's a target in that area. And so they, they bombard that area to try to control the target, but at the same time,

your own cells are being damaged, so your own proteins are being released. Then you have the late innate immune responses starts

to become a little more controlled, a little bit more sensible. Things like dendritic cells, uh, and so on, start to present antigens.

Um, and then that late innate response will then move to the early adaptive response where B cells actually start

to get involved by, by being presented antigens. And then finally, that long-term adaptive immunity comes from the adaptive immune system being, um,

upregulated, right? And, and to have long-term immunity, meaning you, uh, experience a virus now and you want protection from, from a 10 years from now,

you need the, um, the long-term immunity. You need the antibodies being produced by B cells, and you need the immune system to go from the first, uh,

early actors, the innate immune system to the early adaptive, and then finally, the long-term adaptive. So that shuttling through the process

is all dependent on the microbiome, right? The inflammation that's required to signal the immune system is also dependent on the microbiome.

The anti-inflammation, uh, once we go into the adaptive response, is also dependent on the microbiome and the shift of the immune cells from early innate,

late innate, early adaptive, long-term, uh, adaptive, and so on. All of those shifts require signals from the microbiome, right?

So your immune system really cannot function properly without the microbiome signaling. So when we look then beyond your immunity, right?

So your microbiome's vast influence, uh, we focus on things like the crucial gut immune connection, um, you know, but the microbiome impacts everything, right?

Impacts so much more. And also, the immune system that the microbiome impacts, impacts so much more than just defending against, uh,

invading pathogens. The immune system plays a crucial role in the pathology of ly virtually every chronic disease. So understanding

and nurturing your microbiome becomes key to unlocking the overall health, uh, and resilience components that everyone can face if they have a

good, healthy microbiome. So beyond immunity, we've got impacts and everything else like digestion, nutrient absorption, metabolism, appetite control, hormone balance, brain health

and mood detox, and countless of other systems, right? So virtually everything in your body has some dependency on the microbiome, uh, or the other, right?

So shifting the focus then, right? How do we shift the focus to improve how the immune system functions with the microbiome, uh,

in the perspective, right? So we really want to heal the terrain. Number one, rest lasting relief, uh, requires addressing root causes.

So looking at things like barrier integrity, somebody have leaky gut. Is that why they have these autoimmune conditions? Is that why they have all these allergies?

Is that why they have eczema or psoriasis on their skin? Is it being driven by leaky gut? And then microbial imbalances, right?

How many patho do they have? What is their diversity in their gut microbiome? We really have to start thinking about these things

as it result, uh, as it relates to, uh, toxicity, infections, and so on. And then chronic inflammation. You know, what role does clo chronic inflammation play

in this person's pathology of their condition? And if chronic inflammation is a big problem within the condition, then we likely know

that the gut is involved one way or the other, right? Uh, symptom suppression doesn't fix anything. So if you're just taking over the counter drugs

or prescription drugs just to abate the symptoms temporarily, it's not really a healing process, right? So even though you might feel better, the systems

that are undergoing attack and trying to figure out their dominance, those systems are not still functioning normally, right? So, so you can be fooled by, you know,

getting a viral infection and then starting to spike a fever, and then you take a bunch of ibuprofen or acetaminophen,

and then you feel normal again, you feel fine, but it doesn't mean your system isn't sick, and it doesn't mean there aren't big battles going on

in your system, right? So it becomes important to keep in mind as well. And then I want to introduce the five pillar framework

for rebuilding a resilient gut microbiome and a gut immune access, right? Because this is, to me, the most profound and, uh, and

and impactful way of improving your gut microbiome in all contexts, right? So these are the five areas where you have

to do something in the five areas in order to perpetuate the health of the overall microbiome. So number one is food,

and we'll talk a little bit more about that. Number two is stress. You have to manage stress one way or the other.

Number three is lifestyle, which includes exercise, um, you know, walking and then sleep adequately as well. Uh, number four is exposure.

Are you being exposed to too many toxigenic microbes, uh, and toxins? And are you being exposed enough to beneficial microbes within the environment and so on?

And then the final thing is supplementation, right? So supplements can be a really fantastic boost to getting results faster.

Uh, so I don't brush them off at all. I think supplements are really, really important. So let's think about the foods, right? Diversity is king.

Diversity in the, in your diet increases diversity in the gut microbiome. There's no doubt about that at all, right?

There's no if, ands, or buts about it. You need to have diversity. And a large part of the diversity should come from

plant-based foods because those are the primary types of foods that your microbiome likes to consume. Also, within those foods, it's all kinds of compounds like

polyphenols and sterols and so on that the microbiome actually utilizes and, and creates benefit out of it. And then finally, of course, fiber, uh, is really important.

So you want to get 30 to 50 grams of fiber per day, a mix of soluble insoluble. You can kind of do 80, 20, 80% soluble, 20% insoluble.

This feeds a beneficial bacteria. In fact, there's more studies on fiber than any other macronutrient. And the latest meta-analysis, which is a review

of all the studies, uh, that are relevant on this case, show that you can reduce your mortality, all cause mortality

by 10%, for every 10 grams of fiber that you add into your daily diet, right? So that becomes really, really important.

And then finally, you can add in things like prebiotic foods, uh, things like fructooligosaccharides, xylose, oligosaccharide, um, goss, which is galacto oligosaccharides.

And I'm a big fan of oligosaccharides because they feed very specific keystone bacteria in your system. So they're really, really

healthy and they're really good for you. But if your gut's really messed up, you're relatively new to the world of improving your gut,

you may feel a little bit of intolerance there. Uh, and then you wanna reduce and eliminate, um, certain things, right?

So refined carbs, added sugars, artificial sweeteners, heavily processed foods that have pesticides, herbicides, and so on. And potentially even inflammatory fats like low quality meat

and, and saturated fats that may be oxidized and, and have other issues. So simple dietary recommendations. You don't have to completely revamp your diet,

just take baby steps, right? Just slowly start to add polyphenols, uh, into your diet by eating, you know, uh, a handful

or two of berries, uh, that's a great start on its own right. Add some berries, some blueberries, blackberries, and so on.

You can even do some nuts and seeds. And then try to diversify your diet. Try to start with 10, 15 grams of fiber per day, then go up

to 15 to 20, then go up to 25 to 30, and so on. Just work your way up. Cilium husk is one of my favorites.

It's soluble fiber. It's gel forming. It's, it's easy to use. Uh, I get the Organic India version and just mix it in a glass of water

and drink it in the morning after, and then before my afternoon meal, and then again at night. So I'm, I'm hitting my system with fiber a few times.

Prebiotic foods. I love the illegal saccharides. Uh, but some people may be, uh, you know, uh, sensitive to things like, uh, fermented foods and all that.

So you want to consider that and then eliminate things that we know are unhealthy under the stress management, right?

So stress is a big driver of, of chronic inflammation and dysbiosis, uh, and it disrupts the gut lining. So stress induced leaky gut may be one

of the most prevalent sources of leaky gut out there. Even so more than antibiotic use, right? So, so we want to be able to maintain

a parasympathetic state where we can rest and digest, uh, and remain calm and function. We can shift through brainwaves.

We can go to a beta wave where we need to really focus on something and pay attention to it.

Uh, or we can tap into theta waves when we're encountered with something stressful or something that's problematic so we can remain calm throughout these different, uh,

experiences and stages in life. All of that hinges upon being able to maintain a parasympathetic tone. And that parasympathetic tone is really, really important.

There's a number of things you can do is, you know, mindfulness work and so on. Um, and then psychobiotics can be really

useful in this as well. Uh, microbiome labs has a psychobiotic called Zen Cope and Sleep that can be very, very useful in this situation

to manage stress at the same time with specific breathing, uh, techniques. Uh, Michael has a, has a number of those things,

and I'm sure he has masterclasses and all on that. Uh, Qigong vagus nerve stimulation, whether with a device or with practices like humming and singing and so on.

Uh, nervous system regulation, uh, through, through supplementation or practices like meditation, like walking, um, like sitting down in still stillness,

even if you're not meditating, uh, even using technology like the brain tap. And so, so on many of those things can be quite useful,

but know that you cannot overemphasize the importance of reducing stress, and you have to do it. Anyone that is experiencing gut dysbiosis,

leakiness in the gut and so on, more than likely has some sort of low grade anxiety or stress type of condition, right?

Lifestyle. Let's talk about movement. You want to get moving 10 to 15 mo uh, a minute walks after each meal, maybe 30 minute walks outside of that,

uh, throughout the day. You want to get somewhere around, you know, 140 to 150 minutes, uh, of activity throughout the day.

Some sort of moderate intensity activity, zone two type of activity, right? So movement and activity is critically important because every time you actually contract your muscles, you,

your muscles release these compounds called myokines that can be very favorable for your gut microbiome. That can help seal up the gut, reduce the growth

of pathogenic organisms, uh, improve the growth of beneficial organisms and modulate the immune response as well. Uh, sleep in circadian, of course, we can't over, uh, um,

as state the importance of proper sleep. One of the reasons is because when you sleep, your housekeeping microbes go in, go into function,

and they start cleaning up the gut microbiome and damaged cells and DNA and all of this stuff, right? Um, so we want to be able to sleep

to provide adequate amounts of that cleanup. Uh, connection to social bonds is so important. Most of those blue zones that when you look at it,

a key component that they all share is these centenarians have these great social bonds with their friends, with their family, with their neighbors,

and they go out frequently, they meet with them, have lunch, have tea, sit down on the sidewalk, and just people watch, right?

They have that sense of community, and that's really important. And then finally, meal habits and meal surrounding meal hygiene as well.

You wanna space your meals between five to six hours apart, allowing the migrating mortar complex to function and sweep through before you eat next, right?

So the migrating mortar complex is the hunger pains, and then you start to feel some gurgling and so on.

That is the migrating mortar complex. Moving through the system, you have to eat mindfully, uh, until about 80% full, not to a hundred percent full.

Uh, you also want to take in the food and chew your food very carefully and slowly as well. That becomes a very important part

of the digestive response, right? So, and then you can consider things like intermittent fasting as well. And again, increasing fiber, um, uh, into these, uh,

meal habits, uh, beforehand, can also reduce the amount of food you end up eating and, and, and slow you down in terms of

how fast you are eating and so on. So lifestyle factors are important. Exposure that is get outside, interact with nature,

touch soil, plants, animals, sit down and eat a fruit or sandwich in that space, getting pets, having dogs for an example, improve the microbiome

of the house quite a bit and improve, uh, everyone's immune system as a result of that, right? So studies indicate that, um, that households

with dogs have kids with fewer incidence, rate of allergies, asthma, and so on. At the same time, you don't wanna over sterilize your house

'cause you want to build a microbial environment in the house. You don't want to be in a sterile environment, just the same way.

You don't wanna, uh, sterilize your mouth with mouth washes and so on. So you want your home biome to be alive.

You want your home to be teaming with good beneficial microbes. To that end, uh, having windows and doors open as much

as you can is also a quick benefit or a huge benefit. And then antibiotic awareness, right? When should you use the antibiotics? When you shouldn't?

How do you recover from using antibiotics? If you had to use it, which in many cases you do, what do you do to recover it?

Right? So what are the supplement regimens, the food regimens and all that to recover? And then finally, supplements, right?

Supplements are so important because they accelerate the effect, especially when you have research supplements and you can take the clinical dose

based on the research, right? That's really important. And we have this foundational support for virtually every gut for improving diversity,

improving the interaction of the microbes and the immune system, and then also repairing any sort of damage that has occurred in the gut.

That's the MegaSpore mega pre and the tri Butrin X products, right? They work synergistically, they can overlap, uh, in terms

of their use, uh, but they don't overlap in terms of their systems that they function. Uh, but their functions are all additive, right?

We saw that just with the mega pre and the MegaSpore, the adding the mega pre can almost triple the effect

of the MegaSpore. So this combination is a powerful combination for anybody, especially anybody that may be concerned about immune

response within the system, right? Um, so these are the key foundational strategies using the spore based probiotic. Uh, the, the spore

and the prebiotic together increases amania, if we klum bacteria, prosci in your gut, and of course dramatically increases short-chain

fatty acid production. Uh, and then we've got the precision prebiotics, which are the mega, mega pre that specifically feeds, uh,

beneficial bacteria, uh, in the gut, uh, without feeding any dysfunctional bacteria as well. And then all of these products in especially the tribu next,

improves gut lining support. So we can fix that leakiness in the gut. 'cause we do not want the gut to be leaky, right?

So here are the key, key takeaways. The gut microbiome is a master regulator of the immune system. So in order for your immune system to function properly,

you have to start with rebuilding your gut. Dysbiosis of the imbalance and leaky gut drive, chronic inflammation and immune confusion.

This contributes to things like allergies, autoimmunity, asthma, and so on. Restoring the gut health, uh, through the five pillars.

And you have to do something within the five pillars, right? Food, stress management, lifestyle, uh, you know, uh, exposure.

So lifestyles, exercise, sleep, and so on. Exposure is, are you exposing yourself to good microbes? Are you reducing exposure to bad microbes?

And then supplementation, like I talked about, the MegaSpore mega pre and tribu annex are all foundational to me. And the goal is to restore the body's innate ability

to self-regulate the immune responses by going and addressing all of these root causes in the gut. And building resilience is a journey focused on

consistency, right? So even if you missed a pillar yesterday, it doesn't mean you don't do all five today, right?

It doesn't mean you go, ah, I missed it. I messed it up. I'm gonna restart in a week or two weeks, uh, and so on.

But you want to be consistent, right? Consistency's where all of the benefit happens. And so that is just a portion of it, right?

Uh, and, and there's an opportunity to really understand the full roadmap on how you build your own resilient gut.

'cause there's more aspects to it, right? That's, how's the gallbladder involved? How's the liver involved? What happens at this small bowel at the stomach?

What happens in the mouth, for example? You know, what are all the things that impact your microbiome? What are all the tools you can use to impact your microbiome

and build a more resilient microbiome? So in addition to this workshop, there's something more that, uh, Michael can fill you in on.

I can thank you, Kiran. That was amazing as always. And everybody, I tried to do the questions I answered about a zillion

and four questions in the q and a and then chat. I couldn't get to all of them, but, um, that's why we're gonna talk about this here.

So there's some Build your Resilient Gut students in here. So if anybody's in here, feel free to chime in in the chat.

Um, this is something we put together with him about six months ago. It has been amazing. There's now over a thousand students.

And a lot, a lot, a lot of the questions that I got asked or that got asked in the q and a

and in the chat are things that are specifically covered in the course. People asking what steps to do this, what for this

that's kind of outside the immune system, uh, focus. 'cause this is just one aspect. So here's my, these are some

of the modules you can click through. I'll talk as you go. These are the three modules are Microbiome Essentials, gut Health 1 0 1,

which which goes through the digestive tract as he was talking about today. This leads to, this leads to this.

I had so many questions in the chat and in the q and a about, I have this issue, um,

but does it relate to this issue? And in that module is where everybody learns how the things relate to each other.

And there was so many questions about leaky gut and how to tell about leaky gut and symptoms of leaky gut

and endotoxemia in module three there. And then there's 25 additional lessons with a ton of different con specific problems about the upstream

causes, problem solving, all of that kind of stuff. We've created tons of checklists and guides and tools. Um, there's way more than this.

This is just a small sampling of them. I think there's about 15 of them, including a feature microbiome guide, symptoms,

checklist, all those kind of things. Um, it goes step by step and you can watch it as many times as you want.

And the lessons are like 5, 10, 15 minutes. So you can go through them, they're short, there's transcripts, there's audio, there's everything.

So you can look at it and watch it in any way that you want to. Um, you can go here. So there's that.

There's live q and As, which we're doing. For those of you who are in here who are BYRG students,

there were two questions in the q and a. And I got an email today. You'll be getting an email tonight.

We're gonna be doing another one in about two weeks. We're gonna do it this week. We had a little

bit of a tech issue. Um, it'll be in May. So there's a quarterly live q and a. We've done two of them already.

You get the transcripts, the audio recordings, all the video lessons, all the guides and tools and checklists. So there's a ton, a ton, a ton. And it goes step by step.

This topic is just one of several, and it is a foundational one 'cause the immune system controls so much, especially

with symptoms and reactions and food sensitivities and things like that. But he does go step-by-step in the course in like restoring

oral tolerance and being able to kind of quell the response. Uh, and we have some bonuses. One of them is mine, other than the q

and a I already talked about. You can skip there. Um, there are a lot of questions in the chat about meditation and stress

and trauma and things like that. 'cause that got brought up. And there's some people in the, in the chat who have like tried everything.

Uh, I have a module in there on stress reduction and nervous system and some breathing techniques. There's one on genetics

and genes that impact the gut and the microbiome. There's an oral microbiome deep dive, which is actually a round table with Kiran and Dr.

Mark Bena, which was super fun to be a fly on the wall for. And then there's a bonus module on how light

and circadian rhythms impact the microbiome in the gut. Now, just those four modules alone are like a pretty awesome

standalone thing. And those are just bonuses that we put in to kind of fill some gaps where we could provide a little bit more

value and a little bit more depth. And for the next two days, I think it's about 48 hours. These are all the deep dive trainings that we've ever done

with Keran over the years. There's gut microbiome immune, which goes even deeper than this one. There's the sibo, there's original Microbiome series webinars.

There's one on Endotoxemia and Leaky Gut and LPS. There's a gut brain connection, um, gut microbiome, autoimmune. There's one on gut microbiome and hormones, the skin biome.

A lot of these are practitioner and professional presentations that he gave at conferences. And we got lucky enough to have the front row seat first.

And we are throwing all of these in for people who purchase the course as well, who wanna go deeper into certain topics.

Gina, you have access to the learning material forever. So, um, this bonus is 48 hours. So there's the recap up on the top.

The regular price for the course is 5 47. That's 50 lessons, audio recordings. Um, you got all the bonuses.

Super bonus, the, the deep dive vault, it value's well over a thousand and you can go to the next one.

Um, but we don't think courses for people to help their gut should cost a thousand dollars. We're not gonna charge 5 47.

We're doing a promo for 347. That's the lowest price the course ever is. And I have personally taken gut courses for close

to 10 times that amount of money that I learned less in than this one. So anybody who bought the course, you already have it.

No need to do anything else. I see. Do I have to buy this again? No, you still have it.

It's in the, it's in the course area. The link is there. I'll put it in the chat. Um, there is the chat right there.

It's, the link is in the chat that covers all the modules, all the lessons, the video recordings, the transcripts,

and it does the, there's a deep dive into the microbiome in module one, which is fascinating and interesting and really educational.

And goes a little bit more into the, the five pillars. There's a five pillars, guide and checklist that helps you implement a lot

of those five pillars, approaches. Then the second module is a mouth to tail tour through the digestive tract and how everything works,

what symptoms may appear when things are out of whack, in which places, what drives those, how to understand the relationships between upstream

and downstream problems where the things are connected, because it's often, like if anybody here has like a bad elbow or shoulder,

or if, if you like hurt your back or your hips, you start limping to offset that, then something else is gonna hurt.

And it's usual. Anybody here's a physical therapist or a massage therapist will tell you it's usually not where the pain is, where the problem originated

or where the problem started. And the same thing goes in the gut. So it teaches you how to kind of analyze it a little bit,

the leaky gut endotoxemia module, and then tons of problem, problem, uh, solving and troubleshooting as well. So this is his first ever consumer course.

I saw a couple questions. We are working on the practitioner certificate program, but for right now, this is the course, this is the consumer

facing patient course, and it's the first time and only time all of Kieran's teaching has been put together in a very simple,

easy to follow format. I saw a lot of people in the chat who are students of BYRG raving about it over there, so you can ask them questions.

And if you got something else to say, you can chime in. I'll answer a couple of the questions in the chat.

Um, you know, I I I wanna just emphasize again on, on what we talked about today with the immune system.

Um, it becomes so important to have a foundationally functioning immune system for everything, right? So, uh, not only your body's defenses,

but of course so that your immune system does not become a source of chronic illness. Uh, and in the case of diabetes and heart disease

and obesity and, uh, Alzheimer's and Parkinson's and all that, our immune system is acting as a source of dysfunction.

Um, and all of that comes from a dysfunctional gut microbiome. So it becomes so important. And, and what we really aim to do

with this course is provide you not only with the understanding, because I think the more you understand the stuff, the, the easier it becomes

to make decisions on what to do and what not to do, right? Um, because with the microbiome, as everyone knows,

there's no magic pill. There's no one thing that you do. Um, you know, there's not one biohack, there's not one,

uh, solution to it. It's a series of decisions you make throughout the day. Uh, and it's a series of what you eat,

what you put on your system, you know, uh, who you hang out with, uh, what your, what your daily routine looks like, right?

What your environment looks like. All of those decisions impact your microbiome. And there's an additive effect and, and an additive effect of negative decisions

that drive your microbiome to dysbiosis or an additive effect of positive decisions that can move your microbiome to towards resilience.

Um, but understanding all how to make all those decisions will come from an understanding of how the system works.

Um, so that's a very important part of the, of the course, is giving you that understanding of how it all works.

And then of course, there's plenty of actionable stuff that we built into their supplements, checklists, you know, ways to monitor your system,

follow your progress, all of that good stuff. And then what we really want is we really want you to also be a beacon

of education in your local communities. Whether it's just your household or your household and your work and, uh, your friends.

You know, once you develop a certain level of understanding, uh, of the microbiome, uh, we want you to be able to share

that with other people as well, because that's how we'll we'll spread the word and, and get, get a grassroots effort on saving

our microbes, right? Uh, and thereby improving our overall outcomes as well. Overall, Yeah, it's, it's really fantastic. Like it is great

and no, you don't need street address, it's all digital Lynn, so it doesn't matter that you're in London. Um, and you can watch it as many times as you want.

The lessons are short and digestible. So if this was a lot for somebody, which it is a lot like,

that was a, an hour of pretty solid training, um, that for example, would be broken into like seven, eight different videos that you can watch.

You can read, you can listen to the transcripts or the listen to the audios. And then we created a lot of guides and checklists

and tools to implement it, because we do know it's a lot. And so you can go with the pace that you can go at,

and there's a lot of suggestions. I saw a lot of questions about like, I can't do this because I can't eat 27 kinds of food because I get bloated.

Or there's a lot of strategy in there about how to do things incrementally. Mm-hmm. How to restore tolerance. Um, Jennifer, there's really no need to add this session

to the course because everything in this session is in the course. Uh, and then More, Yeah. And more. And the immune deep dive video in the vault is

90 minutes, um, of depth on immune system stuff. So there's nothing in this that's not in there. Uh, we pulled the content

for this presentation from the course. So, um, any other, let me see. I can do about, I have about 10 minutes.

Are you, do you gotta We're over, do you gotta run or you got 10 minutes? I can try to ask couple. I've got 10 minutes,

Couple questions. Yeah, I can 10 minutes to do that. Alright. Uh, great presentation. There is a recommended antibiotic protocol.

Um, I email Maryanne, maryanne@rebelhealthtribe.com. Can get you that, but it's also in the course as well. Um, I'm trying to get the link to the shot.

Is anybody else having trouble to get the, okay, there we go. I couldn't, I tried to click to the site to get a URL

for you guys, and for some reason it wouldn't load for me, but my internet is screwy and it might be related to the massive,

I dunno if anybody knows this, but there were massive, massive blackouts and power outages across Europe today. Almost all of Spain and Portugal lost power

for like, the whole day. They think it was like a, a court, uh, uh, like did it Yeah, because it was multiple power grids.

All right. Uh, Deb, you can reach out to me directly through Maryanne. Um, the shop link people want is, if I can get this thing to work on my screen,

my computer's being really weird. Maryanne, can you post a link to the shop in the chat, please? People wanna look for the products.

Um, rebel Health is not related to the microbiome company. Carol, uh, Kiran was the founder of Microbiome Labs, but no longer works with them.

And he formulated some of the, all, most of the products, but now neither of us have an affiliation with Microbiome Labs.

All right. Um, yes, you'll get a copy of the recording tomorrow. Yes. You purchased a course through a webinar

with Kiran and Thera. It's the same course, yes. Mm-hmm. Um, same course, yes. Okay. I am trying to find questions

that aren't like super long and personal medical things. Um, I see one that just popped up. What was the fiber that I personally drink? Yeah.

Um, go ahead. So, so my favorite one is Organic India Cilium Husk. Uh, what I like about it is

that there's nothing added to it. It's only cilium husk, so it's just one ingredient. Um, and cilium husk is a soluble fiber that forms a gel.

Um, it's a, it's a fantastic fiber to eat, uh, in terms of your microbiome, your metabolism, controlling blood sugar, uh, reducing inflammation,

producing short chain fatty acids, all the good things about fiber. Um, and, and here's a couple ways that you can utilize it, right?

So it can be the first thing you eat in the morning when you wake up. Uh, I just did that this morning, for example.

Um, you know, went for a long walk with a, with a weighted vest, um, and then came back and then, uh, had, had the fiber had about, uh, three

or four tablespoons, so maybe it's about 10 to 15 grams of it. Um, and then had some protein breakfast and, uh, you know,

and then took some omegas and, and, uh, a few, uh, supplements with that. Um, and then I'll probably have another two couple table

spoons when I eat my lunch, uh, with the meal itself. So it slows down the, the postprandial or the

after meal glucose spike. Uh, and it also makes you feel full. And so it slows down. Gastric emptying allows your system to digest food better,

and at the same time it gets converted into short chain fatty acids and all that, which improves inflammation, improves your metabolism, and so on.

Uh, probably have another, uh, one or two tablespoons with dinner. And then finally, uh, if needed, another one or two tablespoons, uh, before bed.

But at least the three times a day, I just add the tablespoon. I just mix it in water and drink the whole

thing down before eating. Alright. Um, no, the individual modules are not available for purchase. It's all part of the course.

Um, yes, acid reflux is talked with a lot, Lynn. Mm-hmm. And, and the stomach and upper GI issues. Uh, Kathleen email

maryanne@revelhealthtribe.com, and she'll get you access to the course if you can't get in. Um, all right, I'm trying to, just, a lot

of the questions are like really long and a lot of them are answered in the course, You know, and Victoria brings up an important point.

She says her gut would blow up with all that sodium. Um, and that's the thing you wanna, you can do it incrementally, right?

Of course. You wouldn't start with 15 to 30 grams a day in the beginning, especially if you're not consuming a good amount of fiber right now.

So you could start with a teaspoon of it, um, mix it into food or mix it into something and consume it.

Go slow and adapt to it, um, you know, and, and take it with the spores, for example, with MegaSpore.

Uh, and then the spores will help with the utilization of it. So, so go slow, uh, don't think with any of these changes

that you have to go, you know, full bore right out of the gate, right? So you could, you could start with small incremental steps

with everything, um, and just build up, uh, over time as your system adapts to it. Alright, I can do a couple more

and then I gotta run, I gotta help with bedtime. It is, for those who don't know, I live in Italy,

so it's nighttime and I have a toddler, and if I miss bedtime, I can in big trouble. Um, I'm trying to, almost all

of the questions are answered in the course. Um, radiation IgE, how would one know without testing if they have leaky gut?

You mentioned like, almost everybody probably at this point has some degree of it. Yeah. And I know this could be a two hour answer,

so it was probably the wrong one to pull, but I saw it, it was short and I grabbed it.

Yeah, I mean, I just, uh, I would just presume you have it, uh, because, and, and then you wanna treat it, right?

So what does that mean? Treating it, it means diversifying the gut microbiome. So all the things we talked about within this,

within this talk itself to diversify the dietary changes, the, you know, management of stress, the exposure, the supplements, um,

and for some reason if you don't have leaky gut and you did all those things, it's still absolutely wonderful, right?

One of the, one of the best predictors of longevity, uh, and resilience is how diverse your gut microbiome is, right?

So it's a, it's an interesting, uh, condition because the condition is driven by a lack of diversity. And so one of the ways to, to fix it is

to increase diversity, right? And, and increasing diversity independently has all these other benefits to it. And so, um, I would just presume you do and,

and then work towards the diversity. There's no reason not to. Um, because there's no downside to the diversity, there's no downside

to the things we talked about in the five pillars. Um, and there's no downside to having a gut focused,

um, you know, routine. Um, so, so I would, I would absolutely assume you do and, and work towards treating it and fixing it.

Alright, great answer, great question. Um, alright everybody, uh, Kieran, you can take off. I'll stick around, answer a question or take off. Thank

You everybody. Thank You so much. Give Kieran some love in the chat. Let 'em know you love the presentation.

You're getting lots of love in the chat and, uh, Thank you. We'll see you guys next month for the next workshop.

Um, I hope you guys liked that. Uh, this is a new series and I think that one was awesome.

And so, uh, I'm just looking through Krista. We've tried to do a bunch of stuff with babies, toddlers, moms, teens, kids,

and like, it really, really, really gets low attendance. So we've tried, we did a whole series on babies and kids

before and it got like a fraction of the people. Our average audience is well over the age of babies

and kids, um, which we learned by doing that. But there's a lot of stuff about babies and toddlers and moms, uh, and such in the, the course specifically about

how to work with kids microbiomes and how to facilitate kids microbiomes. Um, Kiran and the founders of Microbiome Labs are no longer affiliated

with Microbiome Labs, correct, Delinda 'cause uh, the company was sold about two years ago to Novozyme, which is a Danish company

that primarily makes enzymes and probiotics. Uh, all the formulas are the same, all the products are the same. A lot of the people are the same. But, uh, Kiran now works

with about eight different companies, I think, um, ours being one of them, luckily, and creating these courses. So a little behind the scenes note, uh,

I finished the, a lot of the content slides for module one of the practitioner certificate course today. So, um, that's gonna be something,

and it's gonna be coming out in August, just so everybody knows. Um, for any practitioners who, and this for, for those

who are wondering if you're a practitioner, the Build Your Resilient Gut course is more in depth and more valuable than any professional training I

had done previously. So it is totally worth it. And any practitioners who wanna jump from the Build Your Resilient Gut Course

to the practitioner training, which is going to be called Microbiome Clinical Science Certificate, uh, was named like yesterday. Um, we'll credit you

for the amount spent on the Build Your Resilient Gut, uh, course. And then I saw a lot of questions in the chat

around the work that I do, which is more nervous system trauma, somatic therapy, meditation. Um, I'm gonna be doing a training,

a webinar probably in June. Uh, and then in September, October I'm gonna be transitioning to be doing that work full-time.

Uh, so there'll be a lot more coming on that. And I also have recently created a course of my own,

which will be a work, I'm actually calling it start here. So I saw a lot of people in here

and, uh, asking about where do I start or what's the beginning, or, this is a little over my head.

And so, um, I've created, I'm calling it a mini course. It's like six 30 minute videos of different foundations.

And it's based on my 15 years of working in this industry, interviewing 200 or so doctors and practitioners, and the a hundred thousand dollars

and 2000 hours of professional training that I have. I'm putting it all into a very simple start here, do these things, foundations,

because there's so many people who wanna jump straight to complex protocols and testing and all this wild stuff, and they don't have the foundations in place.

So I'm putting together the top recommendations and tips and action steps from 250 interviews all distilled down into a very simple, easy thing to,

to follow, uh, that would be great for anyone. So anyone you wanna share it with that's in your life

that wants to improve their health, that kind of thing. Like a start here way beyond gut and microbiome. Like that's one aspect of it, but it's, it's wide.

Um, My webinar in June will be free. It will be like this. Um, and then I'll teach some stuff.

I'll do some q and a, we'll talk about some things and that's when I'm gonna share the, the course that I'm creating.

Um, but I'm gonna teach a lot of stuff and we'll do all kinds of fun things. 'cause we don't just do pitch webinars here.

If you didn't notice Quran taught for an hour. We talked about the course for five minutes and there's the link again to the course.

Um, my course is just gonna be called Start Here. And his course is called Build Your Resilient Gut. Um, everybody's asking, uh, just,

you'll get emails about my stuff. You don't worry, you're not gonna miss it. Main leaky gut cause of depression,

leaky gut is one contributing factor to depression. But there's a whole lot of different factors that contribute to depression.

And I'm speaking from someone who, as someone who spent most of my life with severe to suicidal depression, um,

discount ends at the end of the week, Julie, for the course. So I'm gonna put the link in the chat one more time.

The bonuses, some of them go away in 48 hours. The discounted price goes away on the weekend. So, um,

There we go. There's the links Part. Should be great. Prereq. Yeah, Derek, it should maybe we'll sell 'em together.

I don't know. Um, there's gonna be some big announcements coming at that webinar also about Rebel Health, about the future, about Kern's work,

about the courses, all of it. It's gonna be a really, really big deal. So it'll be in June. Uh, you'll get emails about it.

It's just gonna be me, but I would recommend coming to it. Uh, glad you're here, Carol. Nice to meet you too.

Alright everybody, thank you so much for hanging out. This was actually, uh, uh, we switch to this time of day when I moved to Europe.

We used to do these in the evening and that's too hard 'cause it's like two in the morning here.

And this is the highest attendance we've ever had during the day at a webinar ever. And it was a Monday and it's the

first time we've ever done a Monday. So I think that Monday's the way. So thank you so much, everybody.

I'll put the link one more time in the chat. Seriously, grab the course if you're interested. It's, it's ama like it should cost over a thousand dollars.

We've had doctors go through it and say they learn more than thousands of dollars they spent on others. And it's so many lessons and it's great

and there's tools and it's really good. And I didn't even announce this. Ah, I've learned how to use circles.

The platform for community building and it's integrated into the course. You're gonna learn about it at this month's q and a for students.

If you sign up this week, you're gonna get invited to the q and a for students, which is in two weeks.

And so sign up this week, come to the q and a in two weeks, you'll learn about the circle community.

We're gonna need moderators so people come, uh, do that. The chat saves by itself, Dirk, I don't have to do it.

Um, thanks Rebecca. Thanks Carol. Thanks Victoria. Thanks Gina. Theresa, everybody c and check out the course. Yes, we're getting, you'll be getting emails about it.

Appreciate everybody, 495 people on live on a Monday afternoon. It was pretty amazing. So thank you guys so much.

Have a good rest of your day.